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1. Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.99 With unknown physiological acceptors

ID:	1.1.99.40
Description:	(R)-2-hydroxyglutarate--pyruvate transhydrogenase.

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UniProtKB Enzyme Link:	UniProtKB 1.1.99.40
BRENDA Enzyme Link:	BRENDA 1.1.99.40
KEGG Enzyme Link:	KEGG1.1.99.40
BioCyc Enzyme Link:	BioCyc 1.1.99.40
ExPASy Enzyme Link:	ExPASy1.1.99.40
EC2PDB Enzyme Link:	EC2PDB 1.1.99.40
ExplorEnz Enzyme Link:	ExplorEnz 1.1.99.40
PRIAM enzyme-specific profiles Link:	PRIAM 1.1.99.40
IntEnz Enzyme Link:	IntEnz 1.1.99.40
MEDLINE Enzyme Link:	MEDLINE 1.1.99.40

RHEA:51612	(R)-2-hydroxyglutarate + oxaloacetate = (R)-malate + 2-oxoglutarate
RULE(radius=1)	[:1]-[C;H0;+0:2](-[:3])=[O;H0;+0:4].[:5]-[CH;+0:6](-[:7])-[OH;+0:8]>>[:5]-[C;H0;+0:6](-[:7])=[O;H0;+0:8].[:1]-[CH;+0:2](-[:3])-[OH;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.	Becker-Kettern J, Paczia N, Conrotte JF, Kay DP, Guignard C, Jung PP, Linster CL	2016 Mar 18	26774271

RHEA:51608	(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate
RULE(radius=1)	[:1]-[C;H0;+0:2](-[:3])=[O;H0;+0:4].[:5]-[CH;+0:6](-[:7])-[OH;+0:8]>>[:5]-[C;H0;+0:6](-[:7])=[O;H0;+0:8].[:1]-[CH;+0:2](-[:3])-[OH;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.	Becker-Kettern J, Paczia N, Conrotte JF, Kay DP, Guignard C, Jung PP, Linster CL	2016 Mar 18	26774271