EC number:1.1.99.41

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.99 With unknown physiological acceptors
ID:1.1.99.41
Description:3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase.
Alternative Name: Tabersonine 3-reductase.
T3R.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.99.41
BRENDA Enzyme Link: BRENDA 1.1.99.41
KEGG Enzyme Link: KEGG1.1.99.41
BioCyc Enzyme Link: BioCyc 1.1.99.41
ExPASy Enzyme Link: ExPASy1.1.99.41
EC2PDB Enzyme Link: EC2PDB 1.1.99.41
ExplorEnz Enzyme Link: ExplorEnz 1.1.99.41
PRIAM enzyme-specific profiles Link: PRIAM 1.1.99.41
IntEnz Enzyme Link: IntEnz 1.1.99.41
MEDLINE Enzyme Link: MEDLINE 1.1.99.41

EC number:1.1.99.41

MSA:

1.1.99.41;
Phylogenetic Tree:

1.1.99.41;
Uniprot:
M-CSA:
RHEA:55388 (3R)-3-hydroxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[NH;+0:4]-[*:5]>>[*:1]-[C;H0;+0:2](-[*:3])=[N;H0;+0:4]-[*:5]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast.Qu Y, Easson ML, Froese J, Simionescu R, Hudlicky T, De Luca V2015 May 1225918424
RHEA:52484 (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[NH;+0:4]-[*:5]>>[*:1]-[C;H0;+0:2](-[*:3])=[N;H0;+0:4]-[*:5]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast.Qu Y, Easson ML, Froese J, Simionescu R, Hudlicky T, De Luca V2015 May 1225918424