EC number:1.11.1.12

Enzyme

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EC Tree
     1. Oxidoreductases
        1.11 Acting on a peroxide as acceptor
            1.11.1 Peroxidases
ID:1.11.1.12
Description:Phospholipid-hydroperoxide glutathione peroxidase.
Alternative Name: Peroxidation-inhibiting protein.
Prosite: PDOC00396;
PDB:
PDBScop
1GP1 8057880; 8057881; 8057880; 8057881;
2F8A 8002656; 8002666; 8002656; 8002666;
6ELW
5L71
5H5S
 » show all
Cath: 1.20.1050.10; 3.30.1020.10; 3.40.30.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.11.1.12
BRENDA Enzyme Link: BRENDA 1.11.1.12
KEGG Enzyme Link: KEGG1.11.1.12
BioCyc Enzyme Link: BioCyc 1.11.1.12
ExPASy Enzyme Link: ExPASy1.11.1.12
EC2PDB Enzyme Link: EC2PDB 1.11.1.12
ExplorEnz Enzyme Link: ExplorEnz 1.11.1.12
PRIAM enzyme-specific profiles Link: PRIAM 1.11.1.12
IntEnz Enzyme Link: IntEnz 1.11.1.12
MEDLINE Enzyme Link: MEDLINE 1.11.1.12

EC number:1.11.1.12

MSA:

1.11.1.12;
Phylogenetic Tree:

1.11.1.12;
Uniprot:
M-CSA:
RHEA:19057 a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O
RULE(radius=1) [*:1]-[O;H0;+0:2]-[OH;+0:3].[*:4]-[SH;+0:5].[*:6]-[SH;+0:7]>>[*:1]-[OH;+0:2].[*:4]-[S;H0;+0:5]-[S;H0;+0:7]-[*:6].[OH2;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.Schnurr K, Belkner J, Ursini F, Schewe T, Kühn H1996 Mar 18617728
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.Ursini F, Maiorino M, Gregolin C1985 Mar 293978121
Phospholipid hydroperoxide glutathione peroxidase of rat testis. Gonadotropin dependence and immunocytochemical identification.Roveri A, Casasco A, Maiorino M, Dalan P, Calligaro A, Ursini F1992 Mar 251556123