EC number:1.11.1.15

Enzyme

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EC Tree
     1. Oxidoreductases
        1.11 Acting on a peroxide as acceptor
            1.11.1 Peroxidases
ID:1.11.1.15
Description:Peroxiredoxin.
Alternative Name: TXNPx.
Tryparedoxin peroxidase.
TrxPx.
Thioredoxin peroxidase.
Prx.
PRDX.
Alkyl hydroperoxide reductase C22.
AhpC.
Cath: 1.20.1290.10; 1.20.5.810; 3.30.1020.10; 3.30.1020.20; 3.30.300.20; 3.50.50.60; 3.90.1530.10; 3.40.30.10; 3.40.30.80;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.11.1.15
BRENDA Enzyme Link: BRENDA 1.11.1.15
KEGG Enzyme Link: KEGG1.11.1.15
BioCyc Enzyme Link: BioCyc 1.11.1.15
ExPASy Enzyme Link: ExPASy1.11.1.15
EC2PDB Enzyme Link: EC2PDB 1.11.1.15
ExplorEnz Enzyme Link: ExplorEnz 1.11.1.15
PRIAM enzyme-specific profiles Link: PRIAM 1.11.1.15
IntEnz Enzyme Link: IntEnz 1.11.1.15
MEDLINE Enzyme Link: MEDLINE 1.11.1.15

EC number:1.11.1.15

MSA:

1.11.1.15;
Phylogenetic Tree:

1.11.1.15;
Uniprot:
M-CSA:
RHEA:10008 [protein]-dithiol + an hydroperoxide = [protein]-disulfide + an alcohol + H2O
RULE(radius=1) [*:1]-[O;H0;+0:2]-[OH;+0:3].[*:4]-[SH;+0:5].[*:6]-[SH;+0:7]>>[*:1]-[OH;+0:2].[*:6]-[S;H0;+0:7]-[S;H0;+0:5]-[*:4].[OH2;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution.Choi HJ, Kang SW, Yang CH, Rhee SG, Ryu SE1998 May9587003
Structure, mechanism and regulation of peroxiredoxins.Wood ZA, Schröder E, Robin Harris J, Poole LB2003 Jan12517450
Peroxiredoxins.Hofmann B, Hecht HJ, Flohé L2002 Mar-Apr12033427
Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate.Seo MS, Kang SW, Kim K, Baines IC, Lee TH, Rhee SG2000 Jul 710751410