EC number:1.11.1.8
| ID: | 1.11.1.8 | ||
|---|---|---|---|
| Description: | Iodide peroxidase. | ||
| Alternative Name: |
TPO. Thyroperoxidase. Thyroid peroxidase. Iodotyrosine deiodinase. Iodotyrosine deiodase. Iodinase. | ||
| Prosite: | PDOC00394; | ||
| PDB: |
|
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.11.1.8 |
| BRENDA Enzyme Link: | BRENDA 1.11.1.8 |
| KEGG Enzyme Link: | KEGG1.11.1.8 |
| BioCyc Enzyme Link: | BioCyc 1.11.1.8 |
| ExPASy Enzyme Link: | ExPASy1.11.1.8 |
| EC2PDB Enzyme Link: | EC2PDB 1.11.1.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.11.1.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.11.1.8 |
| IntEnz Enzyme Link: | IntEnz 1.11.1.8 |
| MEDLINE Enzyme Link: | MEDLINE 1.11.1.8 |
| RHEA:23336 | 2 H(+) + H2O2 + 2 iodide = diiodine + 2 H2O |
| RULE(radius=1) | [H+;H0:1].[H+;H0:2].[I-;H0:3].[I-;H0:4].[OH;+0:5]-[OH;+0:6]>>[I;H0;+0:3]-[I;H0;+0:4].[OH2;+0:5].[OH2;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase. | Taurog A, Dorris ML, Doerge DR | 1996 Jun 1 | 8651700 |
| Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine. | Sun W, Dunford HB | 1993 Feb 9 | 8448141 |
| One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase. | Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I | 1982 Nov 25 | 7142155 |
| Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction. | Gavaret JM, Cahnmann HJ, Nunez J | 1981 Sep 10 | 7021557 |
| Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. | Magnusson RP, Taurog A, Dorris ML | 1984 Jan 10 | 6706930 |
| Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions. | Virion A, Courtin F, Dème D, Michot JL, Kaniewski J, Pommier J | 1985 Oct | 2996435 |
| Structural and functional aspects of thyroid peroxidase. | Ruf J, Carayon P | 2006 Jan 15 | 16098474 |
| RHEA:48956 | [thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O |
| RULE(radius=1) | [*:1]:[cH;+0:2]:[*:3].[H+;H0:4].[I-;H0:5].[OH;+0:6]-[OH;+0:7]>>[*:1]:[c;H0;+0:2](:[*:3])-[I;H0;+0:5].[OH2;+0:6].[OH2;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase. | Taurog A, Dorris ML, Doerge DR | 1996 Jun 1 | 8651700 |
| Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine. | Sun W, Dunford HB | 1993 Feb 9 | 8448141 |
| One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase. | Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I | 1982 Nov 25 | 7142155 |
| Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction. | Gavaret JM, Cahnmann HJ, Nunez J | 1981 Sep 10 | 7021557 |
| Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. | Magnusson RP, Taurog A, Dorris ML | 1984 Jan 10 | 6706930 |
| Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions. | Virion A, Courtin F, Dème D, Michot JL, Kaniewski J, Pommier J | 1985 Oct | 2996435 |
| Structural and functional aspects of thyroid peroxidase. | Ruf J, Carayon P | 2006 Jan 15 | 16098474 |
| RHEA:48960 | [thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O |
| RULE(radius=1) | [*:1]:[cH;+0:2]:[*:3].[H+;H0:4].[I-;H0:5].[OH;+0:6]-[OH;+0:7]>>[*:1]:[c;H0;+0:2](:[*:3])-[I;H0;+0:5].[OH2;+0:6].[OH2;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase. | Taurog A, Dorris ML, Doerge DR | 1996 Jun 1 | 8651700 |
| Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine. | Sun W, Dunford HB | 1993 Feb 9 | 8448141 |
| One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase. | Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I | 1982 Nov 25 | 7142155 |
| Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction. | Gavaret JM, Cahnmann HJ, Nunez J | 1981 Sep 10 | 7021557 |
| Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. | Magnusson RP, Taurog A, Dorris ML | 1984 Jan 10 | 6706930 |
| Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions. | Virion A, Courtin F, Dème D, Michot JL, Kaniewski J, Pommier J | 1985 Oct | 2996435 |
| Structural and functional aspects of thyroid peroxidase. | Ruf J, Carayon P | 2006 Jan 15 | 16098474 |
| RHEA:48964 | 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]:[c;H0;+0:4](:[*:5])-[CH2;+0:6]-[CH;+0:7](-[*:8])-[*:9].[OH;+0:10]-[OH;+0:11]>>[*:8]-[C;H0;+0:7](-[*:9])=[CH2;+0:6].[*:3]:[c;H0;+0:4](:[*:5])-[O;H0;+0:2]-[*:1].[OH2;+0:10].[OH2;+0:11] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase. | Taurog A, Dorris ML, Doerge DR | 1996 Jun 1 | 8651700 |
| Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine. | Sun W, Dunford HB | 1993 Feb 9 | 8448141 |
| One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase. | Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I | 1982 Nov 25 | 7142155 |
| Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction. | Gavaret JM, Cahnmann HJ, Nunez J | 1981 Sep 10 | 7021557 |
| Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. | Magnusson RP, Taurog A, Dorris ML | 1984 Jan 10 | 6706930 |
| Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions. | Virion A, Courtin F, Dème D, Michot JL, Kaniewski J, Pommier J | 1985 Oct | 2996435 |
| Structural and functional aspects of thyroid peroxidase. | Ruf J, Carayon P | 2006 Jan 15 | 16098474 |
| RHEA:48968 | [thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH2;+0:4]-[c;H0;+0:5](:[*:6]):[*:7].[*:8]-[OH;+0:9].[OH;+0:10]-[OH;+0:11]>>[*:1]-[C;H0;+0:2](-[*:3])=[CH2;+0:4].[*:8]-[O;H0;+0:9]-[c;H0;+0:5](:[*:6]):[*:7].[OH2;+0:10].[OH2;+0:11] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase. | Taurog A, Dorris ML, Doerge DR | 1996 Jun 1 | 8651700 |
| Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine. | Sun W, Dunford HB | 1993 Feb 9 | 8448141 |
| One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase. | Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I | 1982 Nov 25 | 7142155 |
| Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction. | Gavaret JM, Cahnmann HJ, Nunez J | 1981 Sep 10 | 7021557 |
| Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. | Magnusson RP, Taurog A, Dorris ML | 1984 Jan 10 | 6706930 |
| Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions. | Virion A, Courtin F, Dème D, Michot JL, Kaniewski J, Pommier J | 1985 Oct | 2996435 |
| Structural and functional aspects of thyroid peroxidase. | Ruf J, Carayon P | 2006 Jan 15 | 16098474 |