EC number:1.12.1.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.12 Acting on hydrogen as donor |
| 1.12.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.12.1.2 |
|---|---|
| Description: | Hydrogen dehydrogenase. |
| Alternative Name: |
NAD-linked hydrogenase. Hydrogenase. H(2):NAD(+) oxidoreductase. Bidirectional hydrogenase. |
| Cath: | 1.20.1080.10; 1.20.5.460; 1.20.5.480; 3.30.70.20; 3.40.50.720; 3.40.50.740; 1.20.950.20; 2.20.25.90; 2.40.40.20; 3.40.228.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.12.1.2 |
| BRENDA Enzyme Link: | BRENDA 1.12.1.2 |
| KEGG Enzyme Link: | KEGG1.12.1.2 |
| BioCyc Enzyme Link: | BioCyc 1.12.1.2 |
| ExPASy Enzyme Link: | ExPASy1.12.1.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.12.1.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.12.1.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.12.1.2 |
| IntEnz Enzyme Link: | IntEnz 1.12.1.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.12.1.2 |
| RHEA:24636 | H2 + NAD(+) = H(+) + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[H;H0;+0:9]-[H;H0;+0:10]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[H+;H0:9] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Hydrogenases I and II from Pyrococcus furiosus. | Ma K, Adams MW | 2001 | 11265463 |
| Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction. | Ma K, Weiss R, Adams MW | 2000 Apr | 10714990 |
| Effect of redox potential on the activation of the NAD-dependent hydrogenase from Alcaligenes eutrophus Z1. | Petrov RR, Utkin IB, Popov VO | 1989 Jan | 2643385 |
| Functional analysis by site-directed mutagenesis of the NAD(+)-reducing hydrogenase from Ralstonia eutropha. | Burgdorf T, De Lacey AL, Friedrich B | 2002 Nov | 12399498 |