EC number:1.13.11.12

Enzyme

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     1. Oxidoreductases
        1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
            1.13.11 With incorporation of two atoms of oxygen
ID:1.13.11.12
Description:Linoleate 13S-lipoxygenase.
Alternative Name: Lipoxidase.
Lipoperoxidase.
Carotene oxidase.
13-lipoxidase.
13-lipoperoxidase.
Prosite: PDOC00077;
PDB:
PDBScop
3DY5 8030397; 8042776; 8030397; 8042776;
1RRL 8029925; 8029927; 8042304; 8042306; 8029925; 8029927; 8042304; 8042306;
1RRH 8029925; 8029927; 8042304; 8042306;
1ROV 8029925; 8029927; 8042304; 8042306;
1NO3 8029925; 8029927; 8042304; 8042306;
 » show all
Cath: 1.20.1050.10; 1.20.245.10; 3.10.450.60; 3.30.1020.10; 4.10.372.10; 4.10.375.10; 3.40.30.10; 2.60.60.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.13.11.12
BRENDA Enzyme Link: BRENDA 1.13.11.12
KEGG Enzyme Link: KEGG1.13.11.12
BioCyc Enzyme Link: BioCyc 1.13.11.12
ExPASy Enzyme Link: ExPASy1.13.11.12
EC2PDB Enzyme Link: EC2PDB 1.13.11.12
ExplorEnz Enzyme Link: ExplorEnz 1.13.11.12
PRIAM enzyme-specific profiles Link: PRIAM 1.13.11.12
IntEnz Enzyme Link: IntEnz 1.13.11.12
MEDLINE Enzyme Link: MEDLINE 1.13.11.12

EC number:1.13.11.12

MSA:

1.13.11.12;
Phylogenetic Tree:

1.13.11.12;
Uniprot:
M-CSA:
RHEA:34495 (9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
RULE(radius=1) [*:1]-[CH2;+0:2]-[CH;+0:3]=[CH;+0:4]-[*:5].[O;H0;+0:6]=[O;H0;+0:7]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[CH;+0:4](-[*:5])-[O;H0;+0:6]-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of a naturally occurring peroxidase-lipoxygenase fusion protein.Koljak R, Boutaud O, Shieh BH, Samel N, Brash AR1997 Sep 269302294
The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide.Oldham ML, Brash AR, Newcomer ME2005 Jan 1115625113
Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution.Minor W, Steczko J, Stec B, Otwinowski Z, Bolin JT, Walter R, Axelrod B1996 Aug 208718858
Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism.Gardner HW1989 Feb 202492826
Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.Bannenberg G, Martínez M, Hamberg M, Castresana C2009 Feb18949503
Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns.Royo J, Vancanneyt G, Pérez AG, Sanz C, Störmann K, Rosahl S, Sánchez-Serrano JJ1996 Aug 308702864
Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts.Bachmann A, Hause B, Maucher H, Garbe E, Vörös K, Weichert H, Wasternack C, Feussner I2002 Oct12452441
RHEA:22780 (9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
RULE(radius=1) [*:1]-[CH2;+0:2]-[CH;+0:3]=[CH;+0:4]-[*:5].[O;H0;+0:6]=[O;H0;+0:7]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[CH;+0:4](-[*:5])-[O;H0;+0:6]-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Overexpression, purification and characterization of human recombinant 15-lipoxygenase.Kühn H, Barnett J, Grunberger D, Baecker P, Chow J, Nguyen B, Bursztyn-Pettegrew H, Chan H, Sigal E1993 Jul 218334154
Secretion of two novel enzymes, manganese 9S-lipoxygenase and epoxy alcohol synthase, by the rice pathogen Magnaporthe salvinii.Wennman A, Oliw EH2013 Mar23233731
Characterization of a methyljasmonate-inducible lipoxygenase from barley (Hordeum vulgare cv. Salome) leaves.Vörös K, Feussner I, Kühn H, Lee J, Graner A, Löbler M, Parthier B, Wasternack C1998 Jan 159492266
Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns.Royo J, Vancanneyt G, Pérez AG, Sanz C, Störmann K, Rosahl S, Sánchez-Serrano JJ1996 Aug 308702864
Manganese lipoxygenase of F. oxysporum and the structural basis for biosynthesis of distinct 11-hydroperoxy stereoisomers.Wennman A, Magnuson A, Hamberg M, Oliw EH2015 Aug26113537
On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant.Coffa G, Imber AN, Maguire BC, Laxmikanthan G, Schneider C, Gaffney BJ, Brash AR2005 Nov 1816157595
Cloning and expression of a lipoxygenase from Pseudomonas aeruginosa 42A2.Vidal-Mas J, Busquets M, Manresa A2005 Apr15803390
Isolation and characterization of a lipoxygenase from Pseudomonas 42A2 responsible for the biotransformation of oleic acid into ( S )-( E )-10-hydroxy-8-octadecenoic acid.Busquets M, Deroncelé V, Vidal-Mas J, Rodríguez E, Guerrero A, Manresa A2004 Feb15028873
Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts.Bachmann A, Hause B, Maucher H, Garbe E, Vörös K, Weichert H, Wasternack C, Feussner I2002 Oct12452441