EC number:1.13.11.16

Enzyme

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     1. Oxidoreductases
        1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
            1.13.11 With incorporation of two atoms of oxygen
ID:1.13.11.16
Description:3-carboxyethylcatechol 2,3-dioxygenase.
Alternative Name: 2,3-dihydroxy-beta-phenylpropionate oxygenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.13.11.16
BRENDA Enzyme Link: BRENDA 1.13.11.16
KEGG Enzyme Link: KEGG1.13.11.16
BioCyc Enzyme Link: BioCyc 1.13.11.16
ExPASy Enzyme Link: ExPASy1.13.11.16
EC2PDB Enzyme Link: EC2PDB 1.13.11.16
ExplorEnz Enzyme Link: ExplorEnz 1.13.11.16
PRIAM enzyme-specific profiles Link: PRIAM 1.13.11.16
IntEnz Enzyme Link: IntEnz 1.13.11.16
MEDLINE Enzyme Link: MEDLINE 1.13.11.16

EC number:1.13.11.16

MSA:

1.13.11.16;
Phylogenetic Tree:

1.13.11.16;
Uniprot:
M-CSA:
RHEA:25054 (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)
RULE(radius=1) [*:1]-[c;H0;+0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[c;H0;+0:8]:1-[OH;+0:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[C;H0;+0:2](=[CH;+0:3]-[CH;+0:4]=[CH;+0:5]-[C;H0;+0:6](-[*:7])=[O;H0;+0:10])-[C;H0;+0:8](=[O;H0;+0:9])-[OH;+0:11]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.Díaz E, Ferrández A, García JL1998 Jun9603882
RHEA:23840 3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)
RULE(radius=1) [*:1]-[c;H0;+0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[c;H0;+0:8]:1-[OH;+0:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[C;H0;+0:2](=[CH;+0:3]-[CH;+0:4]=[CH;+0:5]-[C;H0;+0:6](-[*:7])=[O;H0;+0:11])-[C;H0;+0:8](=[O;H0;+0:9])-[OH;+0:10]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.Díaz E, Ferrández A, García JL1998 Jun9603882
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.Ferrández A, Garciá JL, Díaz E1997 Apr9098055
Catechol dioxygenases from Escherichia coli (MhpB) and Alcaligenes eutrophus (MpcI): sequence analysis and biochemical properties of a third family of extradiol dioxygenases.Spence EL, Kawamukai M, Sanvoisin J, Braven H, Bugg TD1996 Sep8752345
Acid-base catalysis in the extradiol catechol dioxygenase reaction mechanism: site-directed mutagenesis of His-115 and His-179 in Escherichia coli 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB).Mendel S, Arndt A, Bugg TD2004 Oct 2615491145