EC number:1.13.11.18
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) |
| 1.13.11 With incorporation of two atoms of oxygen |
| ID: | 1.13.11.18 |
|---|---|
| Description: | Persulfide dioxygenase. |
| Alternative Name: |
Sulfur oxygenase. Sulfur dioxygenase. |
| Cath: | 3.60.15.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.13.11.18 |
| BRENDA Enzyme Link: | BRENDA 1.13.11.18 |
| KEGG Enzyme Link: | KEGG1.13.11.18 |
| BioCyc Enzyme Link: | BioCyc 1.13.11.18 |
| ExPASy Enzyme Link: | ExPASy1.13.11.18 |
| EC2PDB Enzyme Link: | EC2PDB 1.13.11.18 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.13.11.18 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.13.11.18 |
| IntEnz Enzyme Link: | IntEnz 1.13.11.18 |
| MEDLINE Enzyme Link: | MEDLINE 1.13.11.18 |
EC number:1.13.11.18
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:12981 | H2O + O2 + S-sulfanylglutathione = glutathione + 2 H(+) + sulfite |
| RULE(radius=1) | [*:1]-[S;H0;+0:2]-[SH;+0:3].[O;H0;+0:4]=[O;H0;+0:5].[OH2;+0:6]>>[*:1]-[SH;+0:2].[O;H0;+0:4]=[S;H0;+0:3](-[OH;+0:5])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy. | Pettinati I, Brem J, McDonough MA, Schofield CJ | 2015 May 1 | 25596185 |
| Distribution, diversity, and activities of sulfur dioxygenases in heterotrophic bacteria. | Liu H, Xin Y, Xun L | 2014 Mar | 24389926 |
| Characterization of patient mutations in human persulfide dioxygenase (ETHE1) involved in H2S catabolism. | Kabil O, Banerjee R | 2012 Dec 28 | 23144459 |
| Arabidopsis ETHE1 encodes a sulfur dioxygenase that is essential for embryo and endosperm development. | Holdorf MM, Owen HA, Lieber SR, Yuan L, Adams N, Dabney-Smith C, Makaroff CA | 2012 Sep | 22786886 |
| Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy. | Tiranti V, Viscomi C, Hildebrandt T, Di Meo I, Mineri R, Tiveron C, Levitt MD, Prelle A, Fagiolari G, Rimoldi M, Zeviani M | 2009 Feb | 19136963 |
| The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp. | Rohwerder T, Sand W | 2003 Jul | 12855721 |