EC number:1.13.11.20

Enzyme

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     1. Oxidoreductases
        1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
            1.13.11 With incorporation of two atoms of oxygen
ID:1.13.11.20
Description:Cysteine dioxygenase.
Cath: 2.60.120.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.13.11.20
BRENDA Enzyme Link: BRENDA 1.13.11.20
KEGG Enzyme Link: KEGG1.13.11.20
BioCyc Enzyme Link: BioCyc 1.13.11.20
ExPASy Enzyme Link: ExPASy1.13.11.20
EC2PDB Enzyme Link: EC2PDB 1.13.11.20
ExplorEnz Enzyme Link: ExplorEnz 1.13.11.20
PRIAM enzyme-specific profiles Link: PRIAM 1.13.11.20
IntEnz Enzyme Link: IntEnz 1.13.11.20
MEDLINE Enzyme Link: MEDLINE 1.13.11.20

EC number:1.13.11.20

MSA:

1.13.11.20;
Phylogenetic Tree:

1.13.11.20;
Uniprot:
M-CSA:
RHEA:20441 L-cysteine + O2 = 3-sulfino-L-alanine + H(+)
RULE(radius=1) [*:1]-[SH;+0:2].[O;H0;+0:3]=[O;H0;+0:4]>>[*:1]-[S;H0;+0:2](=[O;H0;+0:3])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Cystein oxygenase. II. Studies on the mechanism of the reaction with 18oxygen.Lombardini JB, Singer TP, Boyer PD1969 Mar 105767301
An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor.Ye S, Wu X, Wei L, Tang D, Sun P, Bartlam M, Rao Z2007 Feb 217135237
Crystal structure of mammalian cysteine dioxygenase. A novel mononuclear iron center for cysteine thiol oxidation.Simmons CR, Liu Q, Huang Q, Hao Q, Begley TP, Karplus PA, Stipanuk MH2006 Jul 716611640
Structure and mechanism of mouse cysteine dioxygenase.McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN Jr2006 Feb 2816492780