EC number:1.13.11.31
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) |
| 1.13.11 With incorporation of two atoms of oxygen |
| ID: | 1.13.11.31 | ||
|---|---|---|---|
| Description: | Arachidonate 12-lipoxygenase. | ||
| Alternative Name: |
12-lipoxygenase. | ||
| Prosite: | PDOC00077; | ||
| PDB: |
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| Cath: | 1.20.245.10; 3.10.450.60; 3.10.450.670; 2.60.60.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.13.11.31 |
| BRENDA Enzyme Link: | BRENDA 1.13.11.31 |
| KEGG Enzyme Link: | KEGG1.13.11.31 |
| BioCyc Enzyme Link: | BioCyc 1.13.11.31 |
| ExPASy Enzyme Link: | ExPASy1.13.11.31 |
| EC2PDB Enzyme Link: | EC2PDB 1.13.11.31 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.13.11.31 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.13.11.31 |
| IntEnz Enzyme Link: | IntEnz 1.13.11.31 |
| MEDLINE Enzyme Link: | MEDLINE 1.13.11.31 |
EC number:1.13.11.31
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:10428 | (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3]=[CH;+0:4]-[*:5].[O;H0;+0:6]=[O;H0;+0:7]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[CH;+0:4](-[*:5])-[O;H0;+0:6]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Site-directed mutagenesis studies on the iron-binding domain and the determinant for the substrate oxygenation site of porcine leukocyte arachidonate 12-lipoxygenase. | Suzuki H, Kishimoto K, Yoshimoto T, Yamamoto S, Kanai F, Ebina Y, Miyatake A, Tanabe T | 1994 Jan 20 | 8305485 |
| cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. | Chen XS, Kurre U, Jenkins NA, Copeland NG, Funk CD | 1994 May 13 | 8188678 |
| Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. | Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA | 2013 May | 23382512 |
| Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation. | Ikei KN, Yeung J, Apopa PL, Ceja J, Vesci J, Holman TR, Holinstat M | 2012 Dec | 22984144 |
| Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases. | Prusakiewicz JJ, Turman MV, Vila A, Ball HL, Al-Mestarihi AH, Di Marzo V, Marnett LJ | 2007 Aug 15 | 17493578 |
| Cloning and expression of an airway epithelial 12-lipoxygenase. | De Marzo N, Sloane DL, Dicharry S, Highland E, Sigal E | 1992 Feb | 1539676 |
| Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes. | Siebert M, Krieg P, Lehmann WD, Marks F, Fürstenberger G | 2001 Apr 1 | 11256953 |