EC number:1.13.11.34
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) |
| 1.13.11 With incorporation of two atoms of oxygen |
| ID: | 1.13.11.34 | ||
|---|---|---|---|
| Description: | Arachidonate 5-lipoxygenase. | ||
| Alternative Name: |
LTA synthase. Leukotriene-A(4) synthase. Delta(5)-lipoxygenase. C-5-lipoxygenase. Arachidonic acid 5-lipoxygenase. Arachidonic 5-lipoxygenase. 5-lipoxygenase. 5-Delta-lipoxygenase. | ||
| Prosite: | PDOC00077; | ||
| PDB: |
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| Cath: | 1.20.245.10; 3.10.450.60; 2.60.60.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.13.11.34 |
| BRENDA Enzyme Link: | BRENDA 1.13.11.34 |
| KEGG Enzyme Link: | KEGG1.13.11.34 |
| BioCyc Enzyme Link: | BioCyc 1.13.11.34 |
| ExPASy Enzyme Link: | ExPASy1.13.11.34 |
| EC2PDB Enzyme Link: | EC2PDB 1.13.11.34 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.13.11.34 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.13.11.34 |
| IntEnz Enzyme Link: | IntEnz 1.13.11.34 |
| MEDLINE Enzyme Link: | MEDLINE 1.13.11.34 |
EC number:1.13.11.34
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:32307 | (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4 |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[CH;+0:6]=[CH;+0:7]-[*:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[CH;+0:4]=[CH;+0:5]-[CH;+0:6]1-[O;H0;+0:9]-[CH;+0:7]-1-[*:8].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Functional characterization of genetic enzyme variations in human lipoxygenases. | Horn T, Reddy Kakularam K, Anton M, Richter C, Reddanna P, Kuhn H | 2013 | 24282679 |
| Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid. | Shimizu T, Rådmark O, Samuelsson B | 1984 Feb | 6322165 |
| Molecular cloning and amino acid sequence of human 5-lipoxygenase. | Matsumoto T, Funk CD, Rådmark O, Höög JO, Jörnvall H, Samuelsson B | 1988 Jan | 2829172 |