EC number:1.13.11.4

Enzyme

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     1. Oxidoreductases
        1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
            1.13.11 With incorporation of two atoms of oxygen
ID:1.13.11.4
Description:Gentisate 1,2-dioxygenase.
Alternative Name: Gentisic acid oxidase.
Gentisate oxygenase.
Cath: 2.60.120.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.13.11.4
BRENDA Enzyme Link: BRENDA 1.13.11.4
KEGG Enzyme Link: KEGG1.13.11.4
BioCyc Enzyme Link: BioCyc 1.13.11.4
ExPASy Enzyme Link: ExPASy1.13.11.4
EC2PDB Enzyme Link: EC2PDB 1.13.11.4
ExplorEnz Enzyme Link: ExplorEnz 1.13.11.4
PRIAM enzyme-specific profiles Link: PRIAM 1.13.11.4
IntEnz Enzyme Link: IntEnz 1.13.11.4
MEDLINE Enzyme Link: MEDLINE 1.13.11.4

EC number:1.13.11.4

MSA:

1.13.11.4;
Phylogenetic Tree:

1.13.11.4;
Uniprot:
M-CSA:
RHEA:18237 2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H(+)
RULE(radius=1) [*:1]-[c;H0;+0:2]1:[cH;+0:3]:[c;H0;+0:4](-[OH;+0:5]):[cH;+0:6]:[cH;+0:7]:[c;H0;+0:8]:1-[OH;+0:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[C;H0;+0:4](=[O;H0;+0:5])-[CH2;+0:6]-[C;H0;+0:7](=[O;H0;+0:10])-[C;H0;+0:8](=[O;H0;+0:9])-[OH;+0:11]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Gentisate 1,2-dioxygenase from Haloferax sp. D1227.Fu W, Oriel P1998 Nov9827334
Gentisate 1,2-dioxygenase from Pseudomonas. Substrate coordination to active site Fe2+ and mechanism of turnover.Harpel MR, Lipscomb JD1990 Dec 252266121
nag genes of Ralstonia (formerly Pseudomonas) sp. strain U2 encoding enzymes for gentisate catabolism.Zhou NY, Fuenmayor SL, Williams PA2001 Jan11133965