EC number:1.13.11.40
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) |
| 1.13.11 With incorporation of two atoms of oxygen |
| ID: | 1.13.11.40 | ||
|---|---|---|---|
| Description: | Arachidonate 8-lipoxygenase. | ||
| Alternative Name: |
8-lipoxygenase. | ||
| Prosite: | PDOC00077; | ||
| PDB: |
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| Cath: | 1.20.245.10; 3.10.450.60; 2.40.180.10; 2.60.60.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.13.11.40 |
| BRENDA Enzyme Link: | BRENDA 1.13.11.40 |
| KEGG Enzyme Link: | KEGG1.13.11.40 |
| BioCyc Enzyme Link: | BioCyc 1.13.11.40 |
| ExPASy Enzyme Link: | ExPASy1.13.11.40 |
| EC2PDB Enzyme Link: | EC2PDB 1.13.11.40 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.13.11.40 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.13.11.40 |
| IntEnz Enzyme Link: | IntEnz 1.13.11.40 |
| MEDLINE Enzyme Link: | MEDLINE 1.13.11.40 |
EC number:1.13.11.40
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:14985 | (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3]=[CH;+0:4]-[*:5].[O;H0;+0:6]=[O;H0;+0:7]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[CH;+0:4](-[*:5])-[O;H0;+0:6]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of a naturally occurring peroxidase-lipoxygenase fusion protein. | Koljak R, Boutaud O, Shieh BH, Samel N, Brash AR | 1997 Sep 26 | 9302294 |
| Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian coral Pseudoplexaura porosa. | Bundy GL, Nidy EG, Epps DE, Mizsak SA, Wnuk RJ | 1986 Jan 15 | 2867091 |
| The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide. | Oldham ML, Brash AR, Newcomer ME | 2005 Jan 11 | 15625113 |
| Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomalla. | Boutaud O, Brash AR | 1999 Nov 19 | 10559269 |