EC number:1.13.11.52
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) |
| 1.13.11 With incorporation of two atoms of oxygen |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.13.11.52 |
| BRENDA Enzyme Link: | BRENDA 1.13.11.52 |
| KEGG Enzyme Link: | KEGG1.13.11.52 |
| BioCyc Enzyme Link: | BioCyc 1.13.11.52 |
| ExPASy Enzyme Link: | ExPASy1.13.11.52 |
| EC2PDB Enzyme Link: | EC2PDB 1.13.11.52 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.13.11.52 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.13.11.52 |
| IntEnz Enzyme Link: | IntEnz 1.13.11.52 |
| MEDLINE Enzyme Link: | MEDLINE 1.13.11.52 |
EC number:1.13.11.52
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:24536 | L-tryptophan + O2 = N-formyl-L-kynurenine |
| RULE(radius=1) | [*:1]-[c;H0;+0:2]1:[*:3]:[*:4]:[nH;+0:5]:[cH;+0:6]:1.[O;H0;+0:7]=[O;H0;+0:8]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:8])-[*:3]:[*:4]-[NH;+0:5]-[CH;+0:6]=[O;H0;+0:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway. | Thomas SR, Stocker R | 1999 | 10731095 |
| Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. | Ball HJ, Yuasa HJ, Austin CJ, Weiser S, Hunt NH | 2009 Mar | 18282734 |
| Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase. | Littlejohn TK, Takikawa O, Truscott RJ, Walker MJ | 2003 Aug 8 | 12766158 |
| RHEA:14189 | D-tryptophan + O2 = N-formyl-D-kynurenine |
| RULE(radius=1) | [*:1]-[c;H0;+0:2]1:[*:3]:[*:4]:[nH;+0:5]:[cH;+0:6]:1.[O;H0;+0:7]=[O;H0;+0:8]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:8])-[*:3]:[*:4]-[NH;+0:5]-[CH;+0:6]=[O;H0;+0:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. | Takikawa O, Yoshida R, Kido R, Hayaishi O | 1986 Mar 15 | 2419335 |
| Molecular evolution and characterization of fungal indoleamine 2,3-dioxygenases. | Yuasa HJ, Ball HJ | 2011 Feb | 21170645 |
| Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. | Metz R, Duhadaway JB, Kamasani U, Laury-Kleintop L, Muller AJ, Prendergast GC | 2007 Aug 1 | 17671174 |
| Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway. | Thomas SR, Stocker R | 1999 | 10731095 |