EC number:1.13.11.6
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) |
| 1.13.11 With incorporation of two atoms of oxygen |
| ID: | 1.13.11.6 |
|---|---|
| Description: | 3-hydroxyanthranilate 3,4-dioxygenase. |
| Alternative Name: |
3-hydroxyanthranilic acid oxidase. 3-hydroxyanthranilic acid dioxygenase. 3-hydroxyanthranilate oxygenase. |
| Cath: | 2.60.120.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.13.11.6 |
| BRENDA Enzyme Link: | BRENDA 1.13.11.6 |
| KEGG Enzyme Link: | KEGG1.13.11.6 |
| BioCyc Enzyme Link: | BioCyc 1.13.11.6 |
| ExPASy Enzyme Link: | ExPASy1.13.11.6 |
| EC2PDB Enzyme Link: | EC2PDB 1.13.11.6 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.13.11.6 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.13.11.6 |
| IntEnz Enzyme Link: | IntEnz 1.13.11.6 |
| MEDLINE Enzyme Link: | MEDLINE 1.13.11.6 |
EC number:1.13.11.6
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:17953 | 3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde |
| RULE(radius=1) | [*:1]-[c;H0;+0:2]1:[c;H0;+0:3](-[*:4]):[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[c;H0;+0:8]:1-[OH;+0:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[C;H0;+0:2](=[C;H0;+0:3](-[*:4])-[CH;+0:5]=[CH;+0:6]-[CH;+0:7]=[O;H0;+0:10])-[C;H0;+0:8](=[O;H0;+0:9])-[OH;+0:11] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The yeast gene YJR025c encodes a 3-hydroxyanthranilic acid dioxygenase and is involved in nicotinic acid biosynthesis. | Kucharczyk R, Zagulski M, Rytka J, Herbert CJ | 1998 Mar 13 | 9539135 |
| Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase. | Malherbe P, Köhler C, Da Prada M, Lang G, Kiefer V, Schwarcz R, Lahm HW, Cesura AM | 1994 May 13 | 7514594 |
| Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from Saccharomyces cerevisiae: a special subgroup of the type III extradiol dioxygenases. | Li X, Guo M, Fan J, Tang W, Wang D, Ge H, Rong H, Teng M, Niu L, Liu Q, Hao Q | 2006 Apr | 16522801 |
| Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis. | Zhang Y, Colabroy KL, Begley TP, Ealick SE | 2005 May 31 | 15909978 |