EC number:1.13.11.62

Enzyme

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     1. Oxidoreductases
        1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
            1.13.11 With incorporation of two atoms of oxygen
ID:1.13.11.62
Description:Linoleate 10R-lipoxygenase.
Alternative Name: 10R-DOX.
10R-dioxygenase.
(10R)-dioxygenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.13.11.62
BRENDA Enzyme Link: BRENDA 1.13.11.62
KEGG Enzyme Link: KEGG1.13.11.62
BioCyc Enzyme Link: BioCyc 1.13.11.62
ExPASy Enzyme Link: ExPASy1.13.11.62
EC2PDB Enzyme Link: EC2PDB 1.13.11.62
ExplorEnz Enzyme Link: ExplorEnz 1.13.11.62
PRIAM enzyme-specific profiles Link: PRIAM 1.13.11.62
IntEnz Enzyme Link: IntEnz 1.13.11.62
MEDLINE Enzyme Link: MEDLINE 1.13.11.62

EC number:1.13.11.62

MSA:

1.13.11.62;
Phylogenetic Tree:

1.13.11.62;
Uniprot:
M-CSA:
RHEA:31695 (9Z,12Z)-octadecadienoate + O2 = (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
RULE(radius=1) [*:1]-[CH;+0:2]=[CH;+0:3]-[CH2;+0:4]-[*:5].[O;H0;+0:6]=[O;H0;+0:7]>>[*:1]-[CH;+0:2](-[CH;+0:3]=[CH;+0:4]-[*:5])-[O;H0;+0:6]-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.Jernerén F, Garscha U, Hoffmann I, Hamberg M, Oliw EH2010 Apr20045744
Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity.Garscha U, Oliw EH2009 May 1519289462