EC number:1.13.99.3

Enzyme

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     1. Oxidoreductases
        1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
            1.13.99 Miscellaneous
ID:1.13.99.3
Description:Tryptophan 2'-dioxygenase.
Alternative Name: TSO.
Tryptophan side-chain oxidase.
Tryptophan side-chain alpha,beta-oxidase.
Indole-3-alkane alpha-hydroxylase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.13.99.3
BRENDA Enzyme Link: BRENDA 1.13.99.3
KEGG Enzyme Link: KEGG1.13.99.3
BioCyc Enzyme Link: BioCyc 1.13.99.3
ExPASy Enzyme Link: ExPASy1.13.99.3
EC2PDB Enzyme Link: EC2PDB 1.13.99.3
ExplorEnz Enzyme Link: ExplorEnz 1.13.99.3
PRIAM enzyme-specific profiles Link: PRIAM 1.13.99.3
IntEnz Enzyme Link: IntEnz 1.13.99.3
MEDLINE Enzyme Link: MEDLINE 1.13.99.3

EC number:1.13.99.3

MSA:

1.13.99.3;
Phylogenetic Tree:

1.13.99.3;
Uniprot:
M-CSA:
RHEA:22620 H(+) + L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH4(+)
RULE(radius=1) [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH;+0:4](-[NH2;+0:5])-[CH2;+0:6]-[*:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:7]-[CH;+0:6](-[OH;+0:10])-[CH;+0:4]=[O;H0;+0:9].[*:1]=[C;H0;+0:2]=[O;H0;+0:3].[NH3;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives.Takai K, Ushiro H, Noda Y, Narumiya S, Tokuyama T1977 Apr 2515995
Isolation, crystallization, and properties of indolyl-3-alkane alpha-hydroxylase. A novel tryptophan-metabolizing enzyme.Roberts J, Rosenfeld HJ1977 Apr 2515994