EC number:1.14.11.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor |
| ID: | 1.14.11.1 |
|---|---|
| Description: | Gamma-butyrobetaine dioxygenase. |
| Alternative Name: |
Gamma-butyrobetaine,2-oxoglutarate dioxygenase. Gamma-butyrobetaine hydroxylase. Gamma-BBH. |
| Cath: | 3.30.2020.30; 3.60.130.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.11.1 |
| BRENDA Enzyme Link: | BRENDA 1.14.11.1 |
| KEGG Enzyme Link: | KEGG1.14.11.1 |
| BioCyc Enzyme Link: | BioCyc 1.14.11.1 |
| ExPASy Enzyme Link: | ExPASy1.14.11.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.11.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.11.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.11.1 |
| IntEnz Enzyme Link: | IntEnz 1.14.11.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.11.1 |
EC number:1.14.11.1
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:24028 | 2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:10].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:11].[*:4]=[C;H0;+0:5]=[O;H0;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of human gamma-butyrobetaine hydroxylase. | Tars K, Rumnieks J, Zeltins A, Kazaks A, Kotelovica S, Leonciks A, Sharipo J, Viksna A, Kuka J, Liepinsh E, Dambrova M | 2010 Aug 6 | 20599753 |