EC number:1.14.11.16
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor |
| ID: | 1.14.11.16 |
|---|---|
| Description: | Peptide-aspartate beta-dioxygenase. |
| Alternative Name: |
Aspartyl/asparaginyl beta-hydroxylase. Aspartate beta-hydroxylase. |
| Cath: | 2.60.120.330; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.11.16 |
| BRENDA Enzyme Link: | BRENDA 1.14.11.16 |
| KEGG Enzyme Link: | KEGG1.14.11.16 |
| BioCyc Enzyme Link: | BioCyc 1.14.11.16 |
| ExPASy Enzyme Link: | ExPASy1.14.11.16 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.11.16 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.11.16 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.11.16 |
| IntEnz Enzyme Link: | IntEnz 1.14.11.16 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.11.16 |
EC number:1.14.11.16
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:11508 | 2-oxoglutarate + L-aspartyl-[protein] + O2 = 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:10].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:11].[*:4]=[C;H0;+0:5]=[O;H0;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Partial purification and characterization of bovine liver aspartyl beta-hydroxylase. | Gronke RS, Welsch DJ, VanDusen WJ, Garsky VM, Sardana MK, Stern AM, Friedman PA | 1990 May 25 | 2187868 |
| Bovine liver aspartyl beta-hydroxylase. Purification and characterization. | Wang QP, VanDusen WJ, Petroski CJ, Garsky VM, Stern AM, Friedman PA | 1991 Jul 25 | 1856229 |
| cDNA cloning and expression of bovine aspartyl (asparaginyl) beta-hydroxylase. | Jia S, VanDusen WJ, Diehl RE, Kohl NE, Dixon RA, Elliston KO, Stern AM, Friedman PA | 1992 Jul 15 | 1378441 |
| Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. | Dinchuk JE, Focht RJ, Kelley JA, Henderson NL, Zolotarjova NI, Wynn R, Neff NT, Link J, Huber RM, Burn TC, Rupar MJ, Cunningham MR, Selling BH, Ma J, Stern AA, Hollis GF, Stein RB, Friedman PA | 2002 Apr 12 | 11773073 |