EC number:1.14.11.18
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor |
| ID: | 1.14.11.18 |
|---|---|
| Description: | Phytanoyl-CoA dioxygenase. |
| Alternative Name: |
Phytanoyl-CoA hydroxylase. Phytanoyl-CoA alpha-hydroxylase. Phytanoyl-CoA 2-hydroxylase. Phytanoyl-CoA 2 oxoglutarate dioxygenase. |
| Cath: | 2.60.120.620; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.11.18 |
| BRENDA Enzyme Link: | BRENDA 1.14.11.18 |
| KEGG Enzyme Link: | KEGG1.14.11.18 |
| BioCyc Enzyme Link: | BioCyc 1.14.11.18 |
| ExPASy Enzyme Link: | ExPASy1.14.11.18 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.11.18 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.11.18 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.11.18 |
| IntEnz Enzyme Link: | IntEnz 1.14.11.18 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.11.18 |
EC number:1.14.11.18
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:16065 | 2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:10].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:11].[*:4]=[C;H0;+0:5]=[O;H0;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of PAHX, a Refsum disease gene. | Mihalik SJ, Morrell JC, Kim D, Sacksteder KA, Watkins PA, Gould SJ | 1997 Oct | 9326939 |
| Phytanic acid alpha-oxidation in rat liver peroxisomes. Production of alpha-hydroxyphytanoyl-CoA and formate is enhanced by dioxygenase cofactors. | Mihalik SJ, Rainville AM, Watkins PA | 1995 Sep 1 | 7556205 |
| Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. | McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ | 2005 Dec 9 | 16186124 |
| Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal alpha oxidation of phytanic acid. | Mukherji M, Kershaw NJ, Schofield CJ, Wierzbicki AS, Lloyd MD | 2002 May | 12031666 |