EC number:1.14.11.26
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor |
3D structure
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2JB8;
1W2O;
1W2N;
1W2A;
1W28;
1UOG;
1UOF;
1UOB;
1UO9;
1UNB;
1RXG;
1RXF;
1HJG;
1HJF;
1E5I;
1E5H;
1DCS;
1IPS;
4BB3;
3ZOI;
3ZKY;
3ZKU;
2Y6F;
2Y60;
2WO7;
2VE1;
2VCM;
2VBP;
2VBD;
2VBB;
2VAU;
2JB4;
2IVJ;
2IVI;
2BU9;
2BJS;
1W3X;
1W3V;
1W06;
1W05;
1W04;
1W03;
1UZW;
1QJF;
1QJE;
1QIQ;
1ODN;
1ODM;
1OC1;
1OBN;
1HB4;
1HB3;
1HB2;
1HB1;
1BK0;
1BLZ;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.11.26 |
| BRENDA Enzyme Link: | BRENDA 1.14.11.26 |
| KEGG Enzyme Link: | KEGG1.14.11.26 |
| BioCyc Enzyme Link: | BioCyc 1.14.11.26 |
| ExPASy Enzyme Link: | ExPASy1.14.11.26 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.11.26 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.11.26 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.11.26 |
| IntEnz Enzyme Link: | IntEnz 1.14.11.26 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.11.26 |
EC number:1.14.11.26
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:16805 | 2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]=[C;H0;+0:4](-[OH;+0:5])-[C;H0;+0:6](=[*:7])-[*:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH2;+0:2]-[OH;+0:9].[*:7]=[C;H0;+0:6](-[*:8])-[OH;+0:10].[*:3]=[C;H0;+0:4]=[O;H0;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Refolding and purification of Cephalosporium acremonium deacetoxycephalosporin C synthetase/hydroxylase from granules of recombinant Escherichia coli. | Ghag SK, Brems DN, Hassell TC, Yeh WK | 1996 Oct | 8865604 |
| Characterization of the cefF gene of Nocardia lactamdurans encoding a 3'-methylcephem hydroxylase different from the 7-cephem hydroxylase. | Coque JJ, Enguita FJ, Cardoza RE, Martín JF, Liras P | 1996 Jan | 8703431 |
| Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins. | Martín JF, Gutiérrez S, Fernández FJ, Velasco J, Fierro F, Marcos AT, Kosalkova K | 1994 | 7847890 |
| Deacetoxycephalosporin C hydroxylase of Streptomyces clavuligerus. Purification, characterization, bifunctionality, and evolutionary implication. | Baker BJ, Dotzlaf JE, Yeh WK | 1991 Mar 15 | 2002049 |
| C-terminus mutations of Acremonium chrysogenum deacetoxy/deacetylcephalosporin C synthase with improved activity toward penicillin analogs. | Wu XB, Fan KQ, Wang QH, Yang KQ | 2005 May 1 | 15869968 |
| Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase. | Lloyd MD, Lipscomb SJ, Hewitson KS, Hensgens CM, Baldwin JE, Schofield CJ | 2004 Apr 9 | 14734549 |