Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
ID:1.14.11.29
Description:Hypoxia-inducible factor-proline dioxygenase.
Alternative Name: HIF hydroxylase.
Cath: 2.60.120.620;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.11.29
BRENDA Enzyme Link: BRENDA 1.14.11.29
KEGG Enzyme Link: KEGG1.14.11.29
BioCyc Enzyme Link: BioCyc 1.14.11.29
ExPASy Enzyme Link: ExPASy1.14.11.29
EC2PDB Enzyme Link: EC2PDB 1.14.11.29
ExplorEnz Enzyme Link: ExplorEnz 1.14.11.29
PRIAM enzyme-specific profiles Link: PRIAM 1.14.11.29
IntEnz Enzyme Link: IntEnz 1.14.11.29
MEDLINE Enzyme Link: MEDLINE 1.14.11.29
MSA:

1.14.11.29;

Phylogenetic Tree:

1.14.11.29;

Uniprot:
M-CSA:
RHEA:48400 2-oxoglutarate + [hypoxia-inducible factor alpha subunit]-L-proline + O2 = [hypoxia-inducible factor alpha subunit]-trans-4-hydroxy-L-proline + CO2 + succinate
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:10].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:11].[*:4]=[C;H0;+0:5]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A genetic mechanism for Tibetan high-altitude adaptation.Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG Jr, Koivunen P, Prchal JT2014 Sep25129147
Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.Shao Z, Zhang Y, Powell-Coffman JA2009 Nov19737748
The Skp1 prolyl hydroxylase from Dictyostelium is related to the hypoxia-inducible factor-alpha class of animal prolyl 4-hydroxylases.van der Wel H, Ercan A, West CM2005 Apr 1515705570
Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors.Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hütter J, Schramm M, Flamme I2002 Aug 1612163023
The use of dioxygen by HIF prolyl hydroxylase (PHD1).McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ2002 Jun 1712039559
A conserved family of prolyl-4-hydroxylases that modify HIF.Bruick RK, McKnight SL2001 Nov 911598268
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ2001 Oct 511595184
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr2001 Apr 2011292862
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ2001 Apr 2011292861