EC number:1.14.11.3
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor |
| ID: | 1.14.11.3 |
|---|---|
| Description: | Pyrimidine-deoxynucleoside 2'-dioxygenase. |
| Alternative Name: |
Thymidine dioxygenase. Thymidine 2-oxoglutarate dioxygenase. Thymidine 2'-hydroxylase. Thymidine 2'-dioxygenase. Pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase. Pyrimidine deoxyribonucleoside 2'-hydroxylase. Deoxyuridine 2'-hydroxylase. Deoxyuridine 2'-dioxygenase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.11.3 |
| BRENDA Enzyme Link: | BRENDA 1.14.11.3 |
| KEGG Enzyme Link: | KEGG1.14.11.3 |
| BioCyc Enzyme Link: | BioCyc 1.14.11.3 |
| ExPASy Enzyme Link: | ExPASy1.14.11.3 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.11.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.11.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.11.3 |
| IntEnz Enzyme Link: | IntEnz 1.14.11.3 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.11.3 |
EC number:1.14.11.3
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:21076 | 2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:10].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:11].[*:4]=[C;H0;+0:5]=[O;H0;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Markedly different ascorbate dependencies of the sequential alpha-ketoglutarate dioxygenase reactions catalyzed by an essentially homogeneous thymine 7-hydroxylase from Rhodotorula glutinis. | Warn-Cramer BJ, Macrander LA, Abbott MT | 1983 Sep 10 | 6684117 |
| Thymidine 2'-hydroxylation in Neurospora crassa. | Bankel L, Lindstedt G, Lindstedt S | 1972 Oct 10 | 4265566 |
| Identification of two alpha-ketoglutarate-dependent dioxygenases in extracts of Rhodotorula glutinis catalyzing deoxyuridine hydroxylation. | Stubbe J | 1985 Aug 25 | 4040518 |