EC number:1.14.11.30
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor |
| ID: | 1.14.11.30 |
|---|---|
| Description: | Hypoxia-inducible factor-asparagine dioxygenase. |
| Alternative Name: |
HIF hydroxylase. |
| Cath: | 1.10.287.10; 1.10.287.1010; 2.60.120.1660; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.11.30 |
| BRENDA Enzyme Link: | BRENDA 1.14.11.30 |
| KEGG Enzyme Link: | KEGG1.14.11.30 |
| BioCyc Enzyme Link: | BioCyc 1.14.11.30 |
| ExPASy Enzyme Link: | ExPASy1.14.11.30 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.11.30 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.11.30 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.11.30 |
| IntEnz Enzyme Link: | IntEnz 1.14.11.30 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.11.30 |
EC number:1.14.11.30
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:54268 | 2-oxoglutarate + [hypoxia-inducible factor alpha subunit]-L-asparagine + O2 = [hypoxia-inducible factor alpha subunit]-(3S)-3-hydroxy-L-asparagine + CO2 + succinate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:10].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:11].[*:4]=[C;H0;+0:5]=[O;H0;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. | Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ | 2007 Aug 17 | 17573339 |
| FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. | Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK | 2002 Jun 15 | 12080085 |
| Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. | Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ | 2002 Jul 19 | 12042299 |