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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

ID:	1.14.11.31
Description:	Thebaine 6-O-demethylase.

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UniProtKB Enzyme Link:	UniProtKB 1.14.11.31
BRENDA Enzyme Link:	BRENDA 1.14.11.31
KEGG Enzyme Link:	KEGG1.14.11.31
BioCyc Enzyme Link:	BioCyc 1.14.11.31
ExPASy Enzyme Link:	ExPASy1.14.11.31
EC2PDB Enzyme Link:	EC2PDB 1.14.11.31
ExplorEnz Enzyme Link:	ExplorEnz 1.14.11.31
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.11.31
IntEnz Enzyme Link:	IntEnz 1.14.11.31
MEDLINE Enzyme Link:	MEDLINE 1.14.11.31

RHEA:27477	2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + neopinone + succinate
RULE(radius=1)	[:1]-[CH;+0:2]=[C;H0;+0:3](-[:4])-[O;H0;+0:5]-[CH3;+0:6].[:7]=[C;H0;+0:8](-[OH;+0:9])-[C;H0;+0:10](=[:11])-[:12].[O;H0;+0:13]=[O;H0;+0:14]>>[:1]-[CH2;+0:2]-[C;H0;+0:3](-[:4])=[O;H0;+0:5].[:11]=[C;H0;+0:10](-[:12])-[OH;+0:13].[:7]=[C;H0;+0:8]=[O;H0;+0:9].[CH2;+0:6]=[O;H0;+0:14]
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Core-to-Core	More

Title	Authors	Date	PubMed ID
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.	Hagel JM, Facchini PJ	2010 Apr	20228795