EC number:1.14.11.33

Enzyme

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EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
ID:1.14.11.33
Description:DNA oxidative demethylase.
Alternative Name: Alkylated DNA repair protein.
Cath: 2.60.120.590;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.11.33
BRENDA Enzyme Link: BRENDA 1.14.11.33
KEGG Enzyme Link: KEGG1.14.11.33
BioCyc Enzyme Link: BioCyc 1.14.11.33
ExPASy Enzyme Link: ExPASy1.14.11.33
EC2PDB Enzyme Link: EC2PDB 1.14.11.33
ExplorEnz Enzyme Link: ExplorEnz 1.14.11.33
PRIAM enzyme-specific profiles Link: PRIAM 1.14.11.33
IntEnz Enzyme Link: IntEnz 1.14.11.33
MEDLINE Enzyme Link: MEDLINE 1.14.11.33

EC number:1.14.11.33

MSA:

1.14.11.33;
Phylogenetic Tree:

1.14.11.33;
Uniprot:
M-CSA:
RHEA:30299 2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate
RULE(radius=1) [*;H0;+0:1]-[CH3;+0:2].[*:3]=[C;H0;+0:4](-[OH;+0:5])-[C;H0;+0:6](=[*:7])-[*:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*;H0;+0:1].[*:7]=[C;H0;+0:6](-[*:8])-[OH;+0:9].[*:3]=[C;H0;+0:4]=[O;H0;+0:5].[CH2;+0:2]=[O;H0;+0:10]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.Yi C, Jia G, Hou G, Dai Q, Zhang W, Zheng G, Jian X, Yang CG, Cui Q, He C2010 Nov 1121068844
Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching.Holland PJ, Hollis T2010 Jan 1320084272
A non-heme iron-mediated chemical demethylation in DNA and RNA.Yi C, Yang CG, He C2009 Apr 2119852088
AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli.Falnes PØ, Johansen RF, Seeberg E2002 Sep 1212226668