EC number:1.14.11.40

Enzyme

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EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
ID:1.14.11.40
Description:Enduracididine beta-hydroxylase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.11.40
BRENDA Enzyme Link: BRENDA 1.14.11.40
KEGG Enzyme Link: KEGG1.14.11.40
BioCyc Enzyme Link: BioCyc 1.14.11.40
ExPASy Enzyme Link: ExPASy1.14.11.40
EC2PDB Enzyme Link: EC2PDB 1.14.11.40
ExplorEnz Enzyme Link: ExplorEnz 1.14.11.40
PRIAM enzyme-specific profiles Link: PRIAM 1.14.11.40
IntEnz Enzyme Link: IntEnz 1.14.11.40
MEDLINE Enzyme Link: MEDLINE 1.14.11.40

EC number:1.14.11.40

MSA:

1.14.11.40;
Phylogenetic Tree:

1.14.11.40;
Uniprot:
M-CSA:
RHEA:36603 2-oxoglutarate + L-enduracididine + O2 = (3S)-3-hydroxy-L-enduracididine + CO2 + succinate
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:10].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:11].[*:4]=[C;H0;+0:5]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens.Magarvey NA, Haltli B, He M, Greenstein M, Hucul JA2006 Jun16723579
Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins.Haltli B, Tan Y, Magarvey NA, Wagenaar M, Yin X, Greenstein M, Hucul JA, Zabriskie TM2005 Nov16298295