EC number:1.14.11.42

Enzyme

Download
EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
ID:1.14.11.42
Description:tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.
Cath: 1.10.287.3230; 2.60.120.650;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.11.42
BRENDA Enzyme Link: BRENDA 1.14.11.42
KEGG Enzyme Link: KEGG1.14.11.42
BioCyc Enzyme Link: BioCyc 1.14.11.42
ExPASy Enzyme Link: ExPASy1.14.11.42
EC2PDB Enzyme Link: EC2PDB 1.14.11.42
ExplorEnz Enzyme Link: ExplorEnz 1.14.11.42
PRIAM enzyme-specific profiles Link: PRIAM 1.14.11.42
IntEnz Enzyme Link: IntEnz 1.14.11.42
MEDLINE Enzyme Link: MEDLINE 1.14.11.42

EC number:1.14.11.42

MSA:

1.14.11.42;
Phylogenetic Tree:

1.14.11.42;
Uniprot:
M-CSA:
RHEA:37899 2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:10].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:11].[*:4]=[C;H0;+0:5]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.Kato M, Araiso Y, Noma A, Nagao A, Suzuki T, Ishitani R, Nureki O2011 Mar20972222
Expanding role of the jumonji C domain as an RNA hydroxylase.Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T2010 Nov 520739293