EC number:1.14.11.51

Enzyme

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EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
ID:1.14.11.51
Description:DNA N(6)-methyladenine demethylase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.11.51
BRENDA Enzyme Link: BRENDA 1.14.11.51
KEGG Enzyme Link: KEGG1.14.11.51
BioCyc Enzyme Link: BioCyc 1.14.11.51
ExPASy Enzyme Link: ExPASy1.14.11.51
EC2PDB Enzyme Link: EC2PDB 1.14.11.51
ExplorEnz Enzyme Link: ExplorEnz 1.14.11.51
PRIAM enzyme-specific profiles Link: PRIAM 1.14.11.51
IntEnz Enzyme Link: IntEnz 1.14.11.51
MEDLINE Enzyme Link: MEDLINE 1.14.11.51

EC number:1.14.11.51

MSA:

1.14.11.51;
Phylogenetic Tree:

1.14.11.51;
Uniprot:
M-CSA:
RHEA:49524 2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate
RULE(radius=1) [*:1]-[NH;+0:2]-[CH3;+0:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[NH2;+0:2].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:10].[*:4]=[C;H0;+0:5]=[O;H0;+0:6].[CH2;+0:3]=[O;H0;+0:11]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
DNA methylation on N(6)-adenine in mammalian embryonic stem cells.Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, Liu Y, Byrum SD, Mackintosh SG, Zhong M, Tackett A, Wang G, Hon LS, Fang G, Swenberg JA, Xiao AZ2016 Apr 2127027282