Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
ID:1.14.11.53
Description:mRNA N(6)-methyladenine demethylase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.11.53
BRENDA Enzyme Link: BRENDA 1.14.11.53
KEGG Enzyme Link: KEGG1.14.11.53
BioCyc Enzyme Link: BioCyc 1.14.11.53
ExPASy Enzyme Link: ExPASy1.14.11.53
EC2PDB Enzyme Link: EC2PDB 1.14.11.53
ExplorEnz Enzyme Link: ExplorEnz 1.14.11.53
PRIAM enzyme-specific profiles Link: PRIAM 1.14.11.53
IntEnz Enzyme Link: IntEnz 1.14.11.53
MEDLINE Enzyme Link: MEDLINE 1.14.11.53
MSA:

1.14.11.53;

Phylogenetic Tree:

1.14.11.53;

Uniprot:
M-CSA:
RHEA:49520 2-oxoglutarate + N(6)-methyladenosine in mRNA + O2 = adenosine in mRNA + CO2 + formaldehyde + succinate
RULE(radius=1) [*:1]-[NH;+0:2]-[CH3;+0:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[NH2;+0:2].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:10].[*:4]=[C;H0;+0:5]=[O;H0;+0:6].[CH2;+0:3]=[O;H0;+0:11]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J2014 Jun 2024778178
Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition.Feng C, Liu Y, Wang G, Deng Z, Zhang Q, Wu W, Tong Y, Cheng C, Chen Z2014 Apr 2524616105
Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA2014 Apr24489119
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C2013 Jan 1023177736
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C2011 Oct 1622002720
Crystal structure of the FTO protein reveals basis for its substrate specificity.Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q, Cheng W, Wang J, Feng Y, Chai J2010 Apr 2220376003
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.Jia G, Yang CG, Yang S, Jian X, Yi C, Zhou Z, He C2008 Oct 1518775698