EC number:1.14.11.54
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor |
| ID: | 1.14.11.54 |
|---|---|
| Description: | mRNA N(1)-methyladenine demethylase. |
| Alternative Name: |
ALKBH3. |
| Cath: | 2.60.120.590; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.11.54 |
| BRENDA Enzyme Link: | BRENDA 1.14.11.54 |
| KEGG Enzyme Link: | KEGG1.14.11.54 |
| BioCyc Enzyme Link: | BioCyc 1.14.11.54 |
| ExPASy Enzyme Link: | ExPASy1.14.11.54 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.11.54 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.11.54 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.11.54 |
| IntEnz Enzyme Link: | IntEnz 1.14.11.54 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.11.54 |
EC number:1.14.11.54
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:49516 | 2-oxoglutarate + N(1)-methyladenosine in mRNA + O2 = adenosine in mRNA + CO2 + formaldehyde + succinate |
| RULE(radius=1) | [*:1]:[c;H0;+0:2](=[NH;+0:3]):[n;H0;+0:4](:[*:5])-[CH3;+0:6].[*:7]=[C;H0;+0:8](-[OH;+0:9])-[C;H0;+0:10](=[*:11])-[*:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]:[c;H0;+0:2](-[NH2;+0:3]):[n;H0;+0:4]:[*:5].[*:11]=[C;H0;+0:10](-[*:12])-[OH;+0:13].[*:7]=[C;H0;+0:8]=[O;H0;+0:9].[CH2;+0:6]=[O;H0;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome. | Li X, Xiong X, Wang K, Wang L, Shu X, Ma S, Yi C | 2016 May | 26863410 |
| The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA. | Dominissini D, Nachtergaele S, Moshitch-Moshkovitz S, Peer E, Kol N, Ben-Haim MS, Dai Q, Di Segni A, Salmon-Divon M, Clark WC, Zheng G, Pan T, Solomon O, Eyal E, Hershkovitz V, Han D, Doré LC, Amariglio N, Rechavi G, He C | 2016 Feb 25 | 26863196 |
| DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. | Dango S, Mosammaparast N, Sowa ME, Xiong LJ, Wu F, Park K, Rubin M, Gygi S, Harper JW, Shi Y | 2011 Nov 4 | 22055184 |
| Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. | Sundheim O, Vågbø CB, Bjørås M, Sousa MM, Talstad V, Aas PA, Drabløs F, Krokan HE, Tainer JA, Slupphaug G | 2006 Jul 26 | 16858410 |