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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

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UniProtKB Enzyme Link:	UniProtKB 1.14.11.55
BRENDA Enzyme Link:	BRENDA 1.14.11.55
KEGG Enzyme Link:	KEGG1.14.11.55
BioCyc Enzyme Link:	BioCyc 1.14.11.55
ExPASy Enzyme Link:	ExPASy1.14.11.55
EC2PDB Enzyme Link:	EC2PDB 1.14.11.55
ExplorEnz Enzyme Link:	ExplorEnz 1.14.11.55
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.11.55
IntEnz Enzyme Link:	IntEnz 1.14.11.55
MEDLINE Enzyme Link:	MEDLINE 1.14.11.55

RHEA:45740	2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate
RULE(radius=1)	[:1]-[CH2;+0:2]-[:3].[:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[:8])-[:9].[O;H0;+0:10]=[O;H0;+0:11]>>[:1]-[CH;+0:2](-[:3])-[OH;+0:10].[:8]=[C;H0;+0:7](-[:9])-[OH;+0:11].[:4]=[C;H0;+0:5]=[O;H0;+0:6]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Synthesis of 5-hydroxyectoine from ectoine: crystal structure of the non-heme iron(II) and 2-oxoglutarate-dependent dioxygenase EctD.	Reuter K, Pittelkow M, Bursy J, Heine A, Craan T, Bremer E	2010 May 14	20498719
Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses.	Bursy J, Kuhlmann AU, Pittelkow M, Hartmann H, Jebbar M, Pierik AJ, Bremer E	2008 Dec	18849444
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.	Bursy J, Pierik AJ, Pica N, Bremer E	2007 Oct 26	17636255