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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

ID:	1.14.11.6
Description:	Thymine dioxygenase.
Alternative Name:	Thymine,2-oxoglutarate dioxygenase. Thymine 7-hydroxylase.
Cath:	1.20.120.1440;

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UniProtKB Enzyme Link:	UniProtKB 1.14.11.6
BRENDA Enzyme Link:	BRENDA 1.14.11.6
KEGG Enzyme Link:	KEGG1.14.11.6
BioCyc Enzyme Link:	BioCyc 1.14.11.6
ExPASy Enzyme Link:	ExPASy1.14.11.6
EC2PDB Enzyme Link:	EC2PDB 1.14.11.6
ExplorEnz Enzyme Link:	ExplorEnz 1.14.11.6
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.11.6
IntEnz Enzyme Link:	IntEnz 1.14.11.6
MEDLINE Enzyme Link:	MEDLINE 1.14.11.6

RHEA:10316	2-oxoglutarate + O2 + thymine = 5-hydroxymethyluracil + CO2 + succinate
RULE(radius=1)	[:1]-[CH3;+0:2].[:3]=[C;H0;+0:4](-[OH;+0:5])-[C;H0;+0:6](=[:7])-[:8].[O;H0;+0:9]=[O;H0;+0:10]>>[:1]-[CH2;+0:2]-[OH;+0:9].[:7]=[C;H0;+0:6](-[:8])-[OH;+0:10].[:3]=[C;H0;+0:4]=[O;H0;+0:5]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Markedly different ascorbate dependencies of the sequential alpha-ketoglutarate dioxygenase reactions catalyzed by an essentially homogeneous thymine 7-hydroxylase from Rhodotorula glutinis.	Warn-Cramer BJ, Macrander LA, Abbott MT	1983 Sep 10	6684117
Catalysis of three sequential dioxygenase reactions by thymine 7-hydroxylase.	Liu CK, Hsu CA, Abbott MT	1973 Nov	4274083
Oxygenases involved in thymine and thymidine metabolism in Neurospora crassa.	Bankel L, Holme E, Lindstedt G, Lindstedt S	1972 Mar 15	11946494