EC number:1.14.11.7

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
ID:1.14.11.7
Description:Procollagen-proline 3-dioxygenase.
Alternative Name: Prolyl 3-hydroxylase.
Proline,2-oxoglutarate 3-dioxygenase.
Procollagen-proline,2-oxoglutarate 3-dioxygenase.
Prosite: PDOC51471;
PDB:
PDBScop
Cath: 1.10.1720.10; 2.60.120.330;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.11.7
BRENDA Enzyme Link: BRENDA 1.14.11.7
KEGG Enzyme Link: KEGG1.14.11.7
BioCyc Enzyme Link: BioCyc 1.14.11.7
ExPASy Enzyme Link: ExPASy1.14.11.7
EC2PDB Enzyme Link: EC2PDB 1.14.11.7
ExplorEnz Enzyme Link: ExplorEnz 1.14.11.7
PRIAM enzyme-specific profiles Link: PRIAM 1.14.11.7
IntEnz Enzyme Link: IntEnz 1.14.11.7
MEDLINE Enzyme Link: MEDLINE 1.14.11.7

EC number:1.14.11.7

MSA:

1.14.11.7;
Phylogenetic Tree:

1.14.11.7;
Uniprot:
M-CSA:
RHEA:22872 2-oxoglutarate + L-prolyl-[procollagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[procollagen]
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:10].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:11].[*:4]=[C;H0;+0:5]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A rapid assay for prolyl 3-hydroxylase activity.Risteli J, Tryggvason K, Kivirikko KI1978 Feb204218
Prolyl 3-hydroxylase: partial characterization of the enzyme from rat kidney cortex.Risteli J, Tryggvason K, Kivirikko KI1977 Mar 1191255
Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV.Tiainen P, Pasanen A, Sormunen R, Myllyharju J2008 Jul 1118487197
Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes.Vranka JA, Sakai LY, Bächinger HP2004 May 2815044469