EC number:1.14.11.9

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
ID:1.14.11.9
Description:Flavanone 3-dioxygenase.
Alternative Name: Naringenin 3-hydroxylase.
Naringenin 3-dioxygenase.
Flavanone synthase I.
Flavanone 3-hydroxylase.
Flavanone 3-beta-hydroxylase.
(2S)-flavanone 3-hydroxylase.
Prosite: PDOC51471;
PDB:
PDBScop

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.11.9
BRENDA Enzyme Link: BRENDA 1.14.11.9
KEGG Enzyme Link: KEGG1.14.11.9
BioCyc Enzyme Link: BioCyc 1.14.11.9
ExPASy Enzyme Link: ExPASy1.14.11.9
EC2PDB Enzyme Link: EC2PDB 1.14.11.9
ExplorEnz Enzyme Link: ExplorEnz 1.14.11.9
PRIAM enzyme-specific profiles Link: PRIAM 1.14.11.9
IntEnz Enzyme Link: IntEnz 1.14.11.9
MEDLINE Enzyme Link: MEDLINE 1.14.11.9

EC number:1.14.11.9

MSA:

1.14.11.9;
Phylogenetic Tree:

1.14.11.9;
Uniprot:
M-CSA:
RHEA:18621 2-oxoglutarate + a (2S)-flavan-4-one + O2 = a (2R,3R)-dihydroflavonol + CO2 + succinate
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:10].[*:8]=[C;H0;+0:7](-[*:9])-[OH;+0:11].[*:4]=[C;H0;+0:5]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley.Martens S, Forkmann G, Britsch L, Wellmann F, Matern U, Lukacin R2003 Jun 512782296
Flavanone 3beta-hydroxylases from rice: key enzymes for favonol and anthocyanin biosynthesis.Kim JH, Lee YJ, Kim BG, Lim Y, Ahn JH2008 Apr 3018413994