EC number:1.14.11.n2
| ID: | 1.14.11.n2 |
|---|---|
| Description: | Methylcytosine dioxygenase. |
3D structure
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| RHEA:52636 | 2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]=[C;H0;+0:4](-[OH;+0:5])-[C;H0;+0:6](=[*:7])-[*:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH2;+0:2]-[OH;+0:9].[*:7]=[C;H0;+0:6](-[*:8])-[OH;+0:10].[*:3]=[C;H0;+0:4]=[O;H0;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation. | Hu L, Li Z, Cheng J, Rao Q, Gong W, Liu M, Shi YG, Zhu J, Wang P, Xu Y | 2013 Dec 19 | 24315485 |
| Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. | Guo JU, Su Y, Zhong C, Ming GL, Song H | 2011 Apr 29 | 21496894 |
| Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. | Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A | 2009 May 15 | 19372391 |