EC number:1.14.12.16

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
ID:1.14.12.16
Description:2-hydroxyquinoline 5,6-dioxygenase.
Alternative Name: Quinolin-2-ol 5,6-dioxygenase.
Quinolin-2(1H)-one 5,6-dioxygenase.
2-oxo-1,2-dihydroquinoline 5,6-dioxygenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.12.16
BRENDA Enzyme Link: BRENDA 1.14.12.16
KEGG Enzyme Link: KEGG1.14.12.16
BioCyc Enzyme Link: BioCyc 1.14.12.16
ExPASy Enzyme Link: ExPASy1.14.12.16
EC2PDB Enzyme Link: EC2PDB 1.14.12.16
ExplorEnz Enzyme Link: ExplorEnz 1.14.12.16
PRIAM enzyme-specific profiles Link: PRIAM 1.14.12.16
IntEnz Enzyme Link: IntEnz 1.14.12.16
MEDLINE Enzyme Link: MEDLINE 1.14.12.16

EC number:1.14.12.16

MSA:

1.14.12.16;
Phylogenetic Tree:

1.14.12.16;
Uniprot:
M-CSA:
RHEA:10976 H(+) + NADH + O2 + quinolin-2-ol = 5,6-dihydroquinoline-2,5,6-triol + NAD(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]1:[*:10]:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:1.[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH;+0:16]-[CH;+0:12]1-[CH;+0:13]=[CH;+0:14]-[*:9]:[*:10]-[CH;+0:11]-1-[OH;+0:17]
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References

TitleAuthorsDatePubMed ID
Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-methylquinoline degradation.Schach S, Tshisuaka B, Fetzner S, Lingens F1995 Sep 17556204