EC number:1.14.15.19
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.15.19 |
|---|---|
| Description: | C-19 steroid 1-alpha-hydroxylase. |
| Alternative Name: |
CYP260A1. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.15.19 |
| BRENDA Enzyme Link: | BRENDA 1.14.15.19 |
| KEGG Enzyme Link: | KEGG1.14.15.19 |
| BioCyc Enzyme Link: | BioCyc 1.14.15.19 |
| ExPASy Enzyme Link: | ExPASy1.14.15.19 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.15.19 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.15.19 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.15.19 |
| IntEnz Enzyme Link: | IntEnz 1.14.15.19 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.15.19 |
EC number:1.14.15.19
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:50812 | androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[Fe;H0;+0:5]-[*:6].[*:7]-[Fe;H0;+0:8]-[*:9].[H+;H0:10].[H+;H0:11].[O;H0;+0:12]=[O;H0;+0:13]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:12].[*:4]-[Fe+;H0:5]-[*:6].[*:7]-[Fe+;H0:8]-[*:9].[OH2;+0:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids. | Khatri Y, Ringle M, Lisurek M, von Kries JP, Zapp J, Bernhardt R | 2016 Jan 1 | 26478560 |
| Genome mining in Sorangium cellulosum So ce56: identification and characterization of the homologous electron transfer proteins of a myxobacterial cytochrome P450. | Ewen KM, Hannemann F, Khatri Y, Perlova O, Kappl R, Krug D, Hüttermann J, Müller R, Bernhardt R | 2009 Oct 16 | 19696019 |
| RHEA:50340 | 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone = 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[Fe;H0;+0:5]-[*:6].[*:7]-[Fe;H0;+0:8]-[*:9].[H+;H0:10].[H+;H0:11].[O;H0;+0:12]=[O;H0;+0:13]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:12].[*:4]-[Fe+;H0:5]-[*:6].[*:7]-[Fe+;H0:8]-[*:9].[OH2;+0:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids. | Khatri Y, Ringle M, Lisurek M, von Kries JP, Zapp J, Bernhardt R | 2016 Jan 1 | 26478560 |
| Genome mining in Sorangium cellulosum So ce56: identification and characterization of the homologous electron transfer proteins of a myxobacterial cytochrome P450. | Ewen KM, Hannemann F, Khatri Y, Perlova O, Kappl R, Krug D, Hüttermann J, Müller R, Bernhardt R | 2009 Oct 16 | 19696019 |