EC number:1.14.15.8

Enzyme

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EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.15.8
Description:Steroid 15-beta-monooxygenase.
Alternative Name: Steroid 15-beta-hydroxylase.
CYP106A2.
Prosite: PDOC00081;
PDB:
PDBScop
Cath: 1.10.630.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.15.8
BRENDA Enzyme Link: BRENDA 1.14.15.8
KEGG Enzyme Link: KEGG1.14.15.8
BioCyc Enzyme Link: BioCyc 1.14.15.8
ExPASy Enzyme Link: ExPASy1.14.15.8
EC2PDB Enzyme Link: EC2PDB 1.14.15.8
ExplorEnz Enzyme Link: ExplorEnz 1.14.15.8
PRIAM enzyme-specific profiles Link: PRIAM 1.14.15.8
IntEnz Enzyme Link: IntEnz 1.14.15.8
MEDLINE Enzyme Link: MEDLINE 1.14.15.8

EC number:1.14.15.8

MSA:

1.14.15.8;
Phylogenetic Tree:

1.14.15.8;
Uniprot:
M-CSA:
RHEA:27337 2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] = 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[H+;H0:4].[H+;H0:5].[O;H0;+0:6]=[O;H0;+0:7]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:6].[OH2;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of monohydroxy progesterones produced by CYP106A2 using comparative HPLC and electrospray ionisation collision-induced dissociation mass spectrometry.Lisurek M, Kang MJ, Hartmann RW, Bernhardt R2004 Jun 2515178459
Purification and characterization of cytochrome P-450meg.Berg A, Ingelman-Sundberg M, Gustafsson JA1979 Jun 25109432