EC number:1.14.16.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.16.2 | ||
|---|---|---|---|
| Description: | Tyrosine 3-monooxygenase. | ||
| Alternative Name: |
Tyrosine hydroxylase. Tyrosine 3-hydroxylase. L-tyrosine hydroxylase. | ||
| Prosite: | PDOC00316; | ||
| PDB: |
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| Cath: | 1.10.800.10; 3.30.70.260; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.16.2 |
| BRENDA Enzyme Link: | BRENDA 1.14.16.2 |
| KEGG Enzyme Link: | KEGG1.14.16.2 |
| BioCyc Enzyme Link: | BioCyc 1.14.16.2 |
| ExPASy Enzyme Link: | ExPASy1.14.16.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.16.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.16.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.16.2 |
| IntEnz Enzyme Link: | IntEnz 1.14.16.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.16.2 |
EC number:1.14.16.2
| MSA: | |
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| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:18201 | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa |
| RULE(radius=1) | [*:1]-[c;H0;+0:2]1:[c;H0;+0:3](=[*:4]):[nH;+0:5]:[c;H0;+0:6](-[*:7]):[n;H0;+0:8]:[c;H0;+0:9]:1-[*:10].[*:11]:[cH;+0:12]:[*:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[C;H0;+0:2]1(-[OH;+0:14])-[C;H0;+0:3](=[*:4])-[N;H0;+0:5]=[C;H0;+0:6](-[*:7])-[N;H0;+0:8]=[C;H0;+0:9]-1-[*:10].[*:11]:[c;H0;+0:12](:[*:13])-[OH;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site. | Goodwill KE, Sabatier C, Stevens RC | 1998 Sep 29 | 9753429 |
| Cloning of a cDNA coding for active tyrosine hydroxylase in the rainbow trout (Oncorhynchus mykiss): comparison with other hydroxylases and enzymatic expression. | Linard B, Pakdel F, Marmignon MH, Saligaut C | 1998 Sep | 9721717 |
| Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases. | Goodwill KE, Sabatier C, Marks C, Raag R, Fitzpatrick PF, Stevens RC | 1997 Jul | 9228951 |
| Four isoforms of tyrosine hydroxylase are expressed in human brain. | Lewis DA, Melchitzky DS, Haycock JW | 1993 May | 8101641 |
| Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine. | Calvo AC, Pey AL, Miranda-Vizuete A, Døskeland AP, Martinez A | 2011 Feb 15 | 21087208 |