EC number:1.14.18.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.18.2 |
|---|---|
| Description: | CMP-N-acetylneuraminate monooxygenase. |
| Alternative Name: |
Cytidine monophosphoacetylneuraminate monooxygenase. CMP-Neu5Ac hydroxylase. CMP-N-acetylneuraminic acid hydroxylase. CMP-N-acetylneuraminate hydroxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.18.2 |
| BRENDA Enzyme Link: | BRENDA 1.14.18.2 |
| KEGG Enzyme Link: | KEGG1.14.18.2 |
| BioCyc Enzyme Link: | BioCyc 1.14.18.2 |
| ExPASy Enzyme Link: | ExPASy1.14.18.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.18.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.18.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.18.2 |
| IntEnz Enzyme Link: | IntEnz 1.14.18.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.18.2 |
EC number:1.14.18.2
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:16145 | 2 [Fe(II)-cytochrome b5] + CMP-N-acetyl-beta-neuraminate + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + CMP-N-glycoloyl-beta-neuraminate + H2O |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[Fe+2;H0:3].[Fe+2;H0:4].[H+;H0:5].[H+;H0:6].[O;H0;+0:7]=[O;H0;+0:8]>>[*:1]-[CH2;+0:2]-[OH;+0:7].[Fe+3;H0:3].[Fe+3;H0:4].[OH2;+0:8] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. | Bergfeld AK, Pearce OM, Diaz SL, Pham T, Varki A | 2012 Aug 17 | 22692205 |
| Reduction of CMP-N-acetylneuraminic acid hydroxylase activity in engineered Chinese hamster ovary cells using an antisense-RNA strategy. | Chenu S, Grégoire A, Malykh Y, Visvikis A, Monaco L, Shaw L, Schauer R, Marc A, Goergen JL | 2003 Jul 23 | 12880951 |
| Cloning and expression of a membrane-bound CMP-N-acetylneuraminic acid hydroxylase from the starfish Asterias rubens. | Martensen I, Schauer R, Shaw L | 2001 Oct | 11589708 |