EC number:1.14.18.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.18.4 |
|---|---|
| Description: | Phosphatidylcholine 12-monooxygenase. |
| Alternative Name: |
Ricinoleic acid synthase. Oleate Delta(12)-hydroxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.18.4 |
| BRENDA Enzyme Link: | BRENDA 1.14.18.4 |
| KEGG Enzyme Link: | KEGG1.14.18.4 |
| BioCyc Enzyme Link: | BioCyc 1.14.18.4 |
| ExPASy Enzyme Link: | ExPASy1.14.18.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.18.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.18.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.18.4 |
| IntEnz Enzyme Link: | IntEnz 1.14.18.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.18.4 |
EC number:1.14.18.4
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:46360 | 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[Fe+2;H0:4].[Fe+2;H0:5].[H+;H0:6].[H+;H0:7].[O;H0;+0:8]=[O;H0;+0:9]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:8].[Fe+3;H0:4].[Fe+3;H0:5].[OH2;+0:9] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Accumulation of ricinoleic, lesquerolic, and densipolic acids in seeds of transgenic Arabidopsis plants that express a fatty acyl hydroxylase cDNA from castor bean. | Broun P, Somerville C | 1997 Mar | 9085577 |
| Characterization of oleoyl-12-hydroxylase in castor microsomes using the putative substrate, 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine. | Lin JT, McKeon TA, Goodrich-Tanrikulu M, Stafford AE | 1996 Jun | 8784737 |
| Evidence for cytochrome b5 as an electron donor in ricinoleic acid biosynthesis in microsomal preparations from developing castor bean (Ricinus communis L.). | Smith MA, Jonsson L, Stymne S, Stobart K | 1992 Oct 1 | 1417766 |