EC number:1.14.18.5

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.18.5
Description:Sphingolipid C4-monooxygenase.
Alternative Name: Sphingolipid C4-hydroxylase.
Sphinganine C4-monooxygenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.18.5
BRENDA Enzyme Link: BRENDA 1.14.18.5
KEGG Enzyme Link: KEGG1.14.18.5
BioCyc Enzyme Link: BioCyc 1.14.18.5
ExPASy Enzyme Link: ExPASy1.14.18.5
EC2PDB Enzyme Link: EC2PDB 1.14.18.5
ExplorEnz Enzyme Link: ExplorEnz 1.14.18.5
PRIAM enzyme-specific profiles Link: PRIAM 1.14.18.5
IntEnz Enzyme Link: IntEnz 1.14.18.5
MEDLINE Enzyme Link: MEDLINE 1.14.18.5

EC number:1.14.18.5

MSA:

1.14.18.5;
Phylogenetic Tree:

1.14.18.5;
Uniprot:
M-CSA:
RHEA:55808 2 [Fe(II)-cytochrome b5] + a dihydroceramide + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a phytoceramide + H2O
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[Fe+2;H0:4].[Fe+2;H0:5].[H+;H0:6].[H+;H0:7].[O;H0;+0:8]=[O;H0;+0:9]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:8].[Fe+3;H0:4].[Fe+3;H0:5].[OH2;+0:9]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation.Mizutani Y, Kihara A, Igarashi Y2004 Apr 915063729
Identification and characterization of a sphingolipid delta 4-desaturase family.Ternes P, Franke S, Zähringer U, Sperling P, Heinz E2002 Jul 1211937514
Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p.Haak D, Gable K, Beeler T, Dunn T1997 Nov 219368039
Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana.Sperling P, Ternes P, Moll H, Franke S, Zähringer U, Heinz E2001 Apr 611297741
Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae.Grilley MM, Stock SD, Dickson RC, Lester RL, Takemoto JY1998 May 19556590
Sphingolipid functions in Saccharomyces cerevisiae.Dickson RC, Lester RL2002 Jun 1312069845
RHEA:46364 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acylsphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-acyl-(4R)-hydroxysphinganine
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[Fe+2;H0:4].[Fe+2;H0:5].[H+;H0:6].[H+;H0:7].[O;H0;+0:8]=[O;H0;+0:9]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:8].[Fe+3;H0:4].[Fe+3;H0:5].[OH2;+0:9]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation.Mizutani Y, Kihara A, Igarashi Y2004 Apr 915063729
Identification and characterization of a sphingolipid delta 4-desaturase family.Ternes P, Franke S, Zähringer U, Sperling P, Heinz E2002 Jul 1211937514
Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p.Haak D, Gable K, Beeler T, Dunn T1997 Nov 219368039
Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5.Enomoto A, Omae F, Miyazaki M, Kozutsumi Y, Yubisui T, Suzuki A2006 Jul 1516571104
DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine.Omae F, Miyazaki M, Enomoto A, Suzuki M, Suzuki Y, Suzuki A2004 May 114731113
Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana.Sperling P, Ternes P, Moll H, Franke S, Zähringer U, Heinz E2001 Apr 611297741
Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae.Grilley MM, Stock SD, Dickson RC, Lester RL, Takemoto JY1998 May 19556590