EC number:1.14.18.7

Enzyme

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EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.18.7
Description:Dihydroceramide fatty acyl 2-hydroxylase.
Alternative Name: Plant sphingolipid fatty acid 2-hydroxylase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.18.7
BRENDA Enzyme Link: BRENDA 1.14.18.7
KEGG Enzyme Link: KEGG1.14.18.7
BioCyc Enzyme Link: BioCyc 1.14.18.7
ExPASy Enzyme Link: ExPASy1.14.18.7
EC2PDB Enzyme Link: EC2PDB 1.14.18.7
ExplorEnz Enzyme Link: ExplorEnz 1.14.18.7
PRIAM enzyme-specific profiles Link: PRIAM 1.14.18.7
IntEnz Enzyme Link: IntEnz 1.14.18.7
MEDLINE Enzyme Link: MEDLINE 1.14.18.7

EC number:1.14.18.7

MSA:

1.14.18.7;
Phylogenetic Tree:

1.14.18.7;
Uniprot:
M-CSA:
RHEA:46512 2 [Fe(II)-cytochrome b5] + a N-(1,2-saturated acyl)sphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a N-[(2'R)-hydroxyacyl]sphinganine + H2O
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[Fe+2;H0:4].[Fe+2;H0:5].[H+;H0:6].[H+;H0:7].[O;H0;+0:8]=[O;H0;+0:9]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:8].[Fe+3;H0:4].[Fe+3;H0:5].[OH2;+0:9]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Plant sphingolipid fatty acid 2-hydroxylases have unique characters unlike their animal and fungus counterparts.Nagano M, Uchimiya H, Kawai-Yamada M2012 Nov22918503
Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses.Nagano M, Takahara K, Fujimoto M, Tsutsumi N, Uchimiya H, Kawai-Yamada M2012 Jul22635113
Functional association of cell death suppressor, Arabidopsis Bax inhibitor-1, with fatty acid 2-hydroxylation through cytochrome b₅.Nagano M, Ihara-Ohori Y, Imai H, Inada N, Fujimoto M, Tsutsumi N, Uchimiya H, Kawai-Yamada M2009 Apr19054355