EC number:1.14.19.22
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.22 |
|---|---|
| Description: | Acyl-lipid omega-6 desaturase (cytochrome b5). |
| Alternative Name: |
Phosphatidylcholine desaturase. Oleoyl-CoA desaturase. Oleate desaturase. Linoleate synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.22 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.22 |
| KEGG Enzyme Link: | KEGG1.14.19.22 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.22 |
| ExPASy Enzyme Link: | ExPASy1.14.19.22 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.22 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.22 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.22 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.22 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.22 |
EC number:1.14.19.22
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:46332 | 2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Evidence for an oleoyl phosphatidylcholine desaturase in microsomal preparations from cotyledons of safflower (Carthamus tinctorius) seed. | Slack CR, Roughan PG, Browse J | 1979 Jun 1 | 475773 |
| Electron-transport components of the 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine delta 12-desaturase (delta 12-desaturase) in microsomal preparations from developing safflower (Carthamus tinctorius L.) cotyledons. | Smith MA, Cross AR, Jones OT, Griffiths WT, Stymne S, Stobart K | 1990 Nov 15 | 2264826 |
| The role of cytochrome b5 in delta 12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.). | Kearns EV, Hugly S, Somerville CR | 1991 Feb 1 | 1989527 |
| Arabidopsis mutants deficient in polyunsaturated fatty acid synthesis. Biochemical and genetic characterization of a plant oleoyl-phosphatidylcholine desaturase. | Miquel M, Browse J | 1992 Jan 25 | 1730697 |
| Characterization of a membrane-bound phospholipid desaturase system of candida lipolytica. | Pugh EL, Kates M | 1975 Mar 24 | 166662 |