EC number:1.14.19.3
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.3 |
|---|---|
| Description: | Acyl-CoA 6-desaturase. |
| Alternative Name: |
Long-chain fatty acid Delta(6)-desaturase. Linoleoyl-coenzyme A desaturase. Linoleoyl-CoA desaturase. Linoleoyl CoA desaturase. Linoleic acid desaturase. Linoleate desaturase. Fatty acid Delta(6)-desaturase. Fatty acid 6-desaturase. Delta(6)-fatty acyl-CoA desaturase. Delta(6)-desaturase. Delta(6)-acyl CoA desaturase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.3 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.3 |
| KEGG Enzyme Link: | KEGG1.14.19.3 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.3 |
| ExPASy Enzyme Link: | ExPASy1.14.19.3 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.3 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.3 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.3 |
EC number:1.14.19.3
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:47144 | (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. | Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM | 2003 May | 12713571 |
| Metabolism of highly unsaturated n-3 and n-6 fatty acids. | Sprecher H | 2000 Jul 19 | 10903473 |
| Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. | Cho HP, Nakamura MT, Clarke SD | 1999 Jan 1 | 9867867 |
| Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes. | Okayasu T, Nagao M, Ishibashi T, Imai Y | 1981 Jan | 7212717 |
| In vivo characterization of the first acyl-CoA Delta6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri. | Domergue F, Abbadi A, Zähringer U, Moreau H, Heinz E | 2005 Jul 15 | 15769252 |
| RHEA:47140 | (9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. | Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM | 2003 May | 12713571 |
| Metabolism of highly unsaturated n-3 and n-6 fatty acids. | Sprecher H | 2000 Jul 19 | 10903473 |
| Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. | Cho HP, Nakamura MT, Clarke SD | 1999 Jan 1 | 9867867 |
| Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes. | Okayasu T, Nagao M, Ishibashi T, Imai Y | 1981 Jan | 7212717 |
| In vivo characterization of the first acyl-CoA Delta6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri. | Domergue F, Abbadi A, Zähringer U, Moreau H, Heinz E | 2005 Jul 15 | 15769252 |