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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

ID:	1.14.19.30
Description:	Acyl-lipid (8-3)-desaturase.
Alternative Name:	Delta(5)-fatty-acid desaturase. Acyl-lipid 5-desaturase.

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UniProtKB Enzyme Link:	UniProtKB 1.14.19.30
BRENDA Enzyme Link:	BRENDA 1.14.19.30
KEGG Enzyme Link:	KEGG1.14.19.30
BioCyc Enzyme Link:	BioCyc 1.14.19.30
ExPASy Enzyme Link:	ExPASy1.14.19.30
EC2PDB Enzyme Link:	EC2PDB 1.14.19.30
ExplorEnz Enzyme Link:	ExplorEnz 1.14.19.30
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.19.30
IntEnz Enzyme Link:	IntEnz 1.14.19.30
MEDLINE Enzyme Link:	MEDLINE 1.14.19.30

RHEA:46264	2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 H2O
RULE(radius=1)	[:1]-[CH2;+0:2]-[CH2;+0:3]-[:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[:1]-[CH;+0:2]=[CH;+0:3]-[:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Identification of a Delta 4 fatty acid desaturase from Thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in Saccharomyces cerevisiae and Brassica juncea.	Qiu X, Hong H, MacKenzie SL	2001 Aug 24	11397798
Isolation of a Delta5-fatty acid desaturase gene from Mortierella alpina.	Michaelson LV, Lazarus CM, Griffiths G, Napier JA, Stobart AK	1998 Jul 24	9668087
Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis.	Zhou XR, Robert SS, Petrie JR, Frampton DM, Mansour MP, Blackburn SI, Nichols PD, Green AG, Singh SP	2007 Mar	17291553
Identification and functional characterization of the moss Physcomitrella patens delta5-desaturase gene involved in arachidonic and eicosapentaenoic acid biosynthesis.	Kaewsuwan S, Cahoon EB, Perroud PF, Wiwat C, Panvisavas N, Quatrano RS, Cove DJ, Bunyapraphatsara N	2006 Aug 4	16728405

RHEA:46260	2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O
RULE(radius=1)	[:1]-[CH2;+0:2]-[CH2;+0:3]-[:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[:1]-[CH;+0:2]=[CH;+0:3]-[:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Isolation of a Delta5-fatty acid desaturase gene from Mortierella alpina.	Michaelson LV, Lazarus CM, Griffiths G, Napier JA, Stobart AK	1998 Jul 24	9668087
Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis.	Zhou XR, Robert SS, Petrie JR, Frampton DM, Mansour MP, Blackburn SI, Nichols PD, Green AG, Singh SP	2007 Mar	17291553
Identification and functional characterization of the moss Physcomitrella patens delta5-desaturase gene involved in arachidonic and eicosapentaenoic acid biosynthesis.	Kaewsuwan S, Cahoon EB, Perroud PF, Wiwat C, Panvisavas N, Quatrano RS, Cove DJ, Bunyapraphatsara N	2006 Aug 4	16728405