EC number:1.14.19.31
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.31 |
|---|---|
| Description: | Acyl-lipid (7-3)-desaturase. |
| Alternative Name: |
Acyl-lipid 4-desaturase. |
3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.31 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.31 |
| KEGG Enzyme Link: | KEGG1.14.19.31 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.31 |
| ExPASy Enzyme Link: | ExPASy1.14.19.31 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.31 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.31 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.31 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.31 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.31 |
EC number:1.14.19.31
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:46256 | 2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of a Delta 4 fatty acid desaturase from Thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in Saccharomyces cerevisiae and Brassica juncea. | Qiu X, Hong H, MacKenzie SL | 2001 Aug 24 | 11397798 |
| A cytochrome b5-containing plastid-located fatty acid desaturase from Chlamydomonas reinhardtii. | Zäuner S, Jochum W, Bigorowski T, Benning C | 2012 Jul | 22562471 |
| Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. | Zhou XR, Robert SS, Petrie JR, Frampton DM, Mansour MP, Blackburn SI, Nichols PD, Green AG, Singh SP | 2007 Mar | 17291553 |
| Identification of a very long chain polyunsaturated fatty acid Delta4-desaturase from the microalga Pavlova lutheri. | Tonon T, Harvey D, Larson TR, Graham IA | 2003 Oct 23 | 14572666 |
| Biosynthesis of docosahexaenoic acid in Euglena gracilis: biochemical and molecular evidence for the involvement of a Delta4-fatty acyl group desaturase. | Meyer A, Cirpus P, Ott C, Schlecker R, Zähringer U, Heinz E | 2003 Aug 19 | 12911321 |
| RHEA:46252 | 2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of a Delta 4 fatty acid desaturase from Thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in Saccharomyces cerevisiae and Brassica juncea. | Qiu X, Hong H, MacKenzie SL | 2001 Aug 24 | 11397798 |
| A cytochrome b5-containing plastid-located fatty acid desaturase from Chlamydomonas reinhardtii. | Zäuner S, Jochum W, Bigorowski T, Benning C | 2012 Jul | 22562471 |
| Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. | Zhou XR, Robert SS, Petrie JR, Frampton DM, Mansour MP, Blackburn SI, Nichols PD, Green AG, Singh SP | 2007 Mar | 17291553 |
| Identification of a very long chain polyunsaturated fatty acid Delta4-desaturase from the microalga Pavlova lutheri. | Tonon T, Harvey D, Larson TR, Graham IA | 2003 Oct 23 | 14572666 |
| Biosynthesis of docosahexaenoic acid in Euglena gracilis: biochemical and molecular evidence for the involvement of a Delta4-fatty acyl group desaturase. | Meyer A, Cirpus P, Ott C, Schlecker R, Zähringer U, Heinz E | 2003 Aug 19 | 12911321 |