EC number:1.14.19.37
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.37 |
|---|---|
| Description: | Acyl-CoA 5-desaturase. |
| Alternative Name: |
Acyl-CoA 5-desaturase (non-methylene-interrupted). |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.37 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.37 |
| KEGG Enzyme Link: | KEGG1.14.19.37 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.37 |
| ExPASy Enzyme Link: | ExPASy1.14.19.37 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.37 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.37 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.37 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.37 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.37 |
EC number:1.14.19.37
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:42160 | (11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[O;H0;+0:5]=[O;H0;+0:6]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[OH2;+0:5].[OH2;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and characterization of a Delta 5-fatty acid desaturase from Caenorhabditis elegans. | Watts JL, Browse J | 1999 Feb 1 | 9917342 |
| Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 Delta5-desaturase responsible for the synthesis of sciadonic acid. | Sayanova O, Haslam R, Venegas Caleron M, Napier JA | 2007 May | 17384161 |
| RHEA:42164 | (11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[O;H0;+0:5]=[O;H0;+0:6]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[OH2;+0:5].[OH2;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and characterization of a Delta 5-fatty acid desaturase from Caenorhabditis elegans. | Watts JL, Browse J | 1999 Feb 1 | 9917342 |
| Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 Delta5-desaturase responsible for the synthesis of sciadonic acid. | Sayanova O, Haslam R, Venegas Caleron M, Napier JA | 2007 May | 17384161 |
| RHEA:46524 | (11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and characterization of a Delta 5-fatty acid desaturase from Caenorhabditis elegans. | Watts JL, Browse J | 1999 Feb 1 | 9917342 |
| Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 Delta5-desaturase responsible for the synthesis of sciadonic acid. | Sayanova O, Haslam R, Venegas Caleron M, Napier JA | 2007 May | 17384161 |
| RHEA:46528 | (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[Fe+2;H0:5].[Fe+2;H0:6].[H+;H0:7].[H+;H0:8].[O;H0;+0:9]=[O;H0;+0:10]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[Fe+3;H0:5].[Fe+3;H0:6].[OH2;+0:9].[OH2;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and characterization of a Delta 5-fatty acid desaturase from Caenorhabditis elegans. | Watts JL, Browse J | 1999 Feb 1 | 9917342 |
| Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 Delta5-desaturase responsible for the synthesis of sciadonic acid. | Sayanova O, Haslam R, Venegas Caleron M, Napier JA | 2007 May | 17384161 |